Results 41 to 50 of about 1,582 (158)

TROY interacts with RKIP to promote glioma development [PDF]

Oncogene, 2018
TROY is a component of the Nogo receptor complex and plays the key role in neuronal survival, migration, and differentiation. Here, we show the up-regulation of TROY in human glioma tissues and cells. Inhibition of TROY expression slowed glioma development in vivo and in vitro. Raf kinase inhibitor (RKIP) was found to interact with TROY.
Liu, Xiujie, Bao, Yinghui, Meng, Wei, Yang, Ping, An, Yi, Ma, Jie, Tang, Yujie, Liu, Zhigang, Lu, Yan, Zhou, Jianfeng, Zhang, Yong, Feng, Jifeng, Gao, Xiaofei, Su, Zhida, Pu, Yingyan, He, Cheng   +15 more
openaire   +2 more sources

Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population. [PDF]

PLoS ONE, 2014
BACKGROUND: Raf-1 kinase inhibitor protein (RKIP) plays a critical role in tumor development by regulating cell functions such as invasion, apoptosis and differentiation.
Qiang Cao, Jian Wang, Mingcong Zhang, Pu Li, Jian Qian, Shaobo Zhang, Lei Zhang, Xiaobing Ju, Meilin Wang, Zhengdong Zhang, Jie Li, Min Gu, Wei Zhang, Chao Qin, Pengfei Shao, Changjun Yin   +15 more
doaj   +1 more source

RKIP Regulates Differentiation-Related Features in Melanocytic Cells [PDF]

Cancers, 2020
Raf Kinase Inhibitor Protein (RKIP) has been extensively reported as an inhibitor of key signaling pathways involved in the aggressive tumor phenotype and shows decreased expression in several types of cancers. However, little is known about RKIP in melanoma or regarding its function in normal cells.
Cristina Penas, Aintzane Apraiz, Iraia Muñoa, Yoana Arroyo-Berdugo, Javier Rasero, Pilar A. Ezkurra, Veronica Velasco, Nerea Subiran, Anja K. Bosserhoff, Santos Alonso, Aintzane Asumendi, Maria D. Boyano   +11 more
openaire   +4 more sources

Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis

Haematologica, 2020
RAS-signaling mutations induce the myelomonocytic differentiation and proliferation of hematopoietic stem and progenitor cells. Moreover, they are important players in the development of myeloid neoplasias.
Veronica Caraffini, Olivia Geiger, Angelika Rosenberger, Stefan Hatzl, Bianca Perfler, Johannes L. Berg, Clarice Lim, Herbert Strobl, Karl Kashofer, Silvia Schauer, Christine Beham-Schmid, Gerald Hoefler, Klaus Geissler, Franz Quehenberger, Walter Kolch, Dimitris Athineos, Karen Blyth, Albert Wölfler, Heinz Sill, Armin Zebisch   +19 more
doaj   +1 more source

Raf Kinase Inhibitory Protein Down-Expression Exacerbates Hepatic Fibrosis In Vivo and In Vitro

Cellular Physiology and Biochemistry, 2016
Background/Aims: Raf kinase inhibitory protein (RKIP) is closely associated with numerous tumors and participates in their development through regulating the growth, apoptosis, invasion and metastasis of tumor cells.
Quanfang Huang, Chunhong Liang, Ling Wei, Jinlan Nie, Shengjuan Lu, Chunyuan Lu, Lang Zhuo, Zhongpeng Lu, Xing Lin   +8 more
doaj   +1 more source

PEBP1/RKIP behavior: a mirror of actin-membrane organization [PDF]

Cellular and Molecular Life Sciences, 2020
Phosphatidylethanolamine-binding protein 1 (PEBP1), a small 21 kDa protein, is implicated in several key processes of the living cell. The deregulation of PEBP1, especially its downregulation, leads to major diseases such as cancer and Alzheimer's disease.
Schoentgen, Françoise, Jonic, Slavica
openaire   +3 more sources

Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation

Frontiers in Molecular Biosciences, 2021
Protein-protein interactions are indispensable physiological processes regulating several biological functions. Despite the availability of structural information on protein-protein complexes, deciphering their complex topology remains an outstanding ...
Shraddha Parate, Shailima Rampogu, Gihwan Lee, Jong Chan Hong, Keun Woo Lee   +4 more
doaj   +1 more source

Urinary RKIP/p-RKIP is a potential diagnostic and prognostic marker of clear cell renal cell carcinoma

Oncotarget, 2017
Clear cell Renal Cell Carcinoma (ccRCC) causes over 13,000 deaths each year, and about 20,000 new cases/year in Europe. In most cases, the causes are unknown and, most importantly, there are no reliable biomarkers for the diagnosis and prognosis of this disease.
Papale M., Vocino G., Lucarelli G., Rutigliano M., Gigante M., Rocchetti M. T., Pesce F., Sanguedolce F., Bufo P., Battaglia M., Stallone G., Grandaliano G., Carrieri G., Gesualdo L., Ranieri E.   +14 more
openaire   +5 more sources

The RhoA dependent anti-metastatic function of RKIP in breast cancer

Scientific Reports, 2021
Raf-1 kinase inhibitor protein was initially discovered as a physiological kinase inhibitor of the MAPK signaling pathway and was later shown to suppress cancer cell invasion and metastasis.
Gardiyawasam Kalpana, Christopher Figy, Jingwei Feng, Claire Tipton, Julius N. De Castro, Vu N. Bach, Clariza Borile, Alexandria LaSalla, Hussain N. Odeh, Miranda Yeung, Rafael Garcia-Mata, Kam C. Yeung   +11 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source