Results 61 to 70 of about 1,582 (158)
Advanced Science, Volume 12, Issue 10, March 13, 2025.BACH1, a basic leucine zipper protein ubiquitously expressed in mammalian tissues, plays a critical role in the regulation of oxidative stress, cell cycle progression, heme homeostasis, and immune responses. It is implicated in cardiovascular diseases, cancer progression, neurodegenerative disorders, and many other diseases.
Xiangxiang Wei +9 more
wiley +1 more source
Neoplasia: An International Journal for Oncology Research, 2013 p53, a strong tumor suppressor protein, is known to be involved in cellular senescence, particularly premature cellular senescence. Oncogenic stresses, such as Ras activation, can initiate p53-mediated senescence, whereas activation of the Ras-mitogen ...
Su-Jin Lee +3 more
doaj +1 more source
Journal of Chemometrics, Volume 39, Issue 2, February 2025.ABSTRACT The analysis of single cell multi‐omics data is a complex task, and many explorative data analysis methods are being used to draw information from such data. This paper compares several of these methods to visualize the output of a mechanistic model under various simulated conditions.
J. A. Westerhuis +5 more
wiley +1 more source
Regulation of RKIP binding to the N‐region of the Raf‐1 kinase [PDF]
FEBS Letters, 2006 The Raf kinase inhibitory protein (RKIP) binds to Raf‐1 interfering with binding of the MEK substrate and potentially also Raf‐1 activation. In response to mitogen stimulation RKIP dissociates from Raf‐1 and later re‐associates. Here, using a combination of mutational approaches, biochemical studies, peptide arrays and plasmon surface resonance ...
Park, Sungdae +7 more
openaire +2 more sources
Food Science &Nutrition, Volume 12, Issue 12, Page 9951-9973, December 2024.This study discussed the therapeutic capacity of various polyphenols, terpenoids, and alkaloids on CRC via the PI3K/Akt/mTOR pathway. Each bioactive component causes various physiological processes, such as triggering free radical production, disruption of mitochondrial membrane potential, cell cycle arrest, inhibition of CRC stem cell migration ...
Kübra Demir +4 more
wiley +1 more source
Advanced Science, Volume 11, Issue 41, November 6, 2024.Understanding the mechanism of cancer‐adipose conversion (CAC) is a critical and complex challenge in cancer treatment. A systems biology approach combining molecular network modeling and experiments is proposed based on energy landscape theory, which provides an important way to identify optimal drug combinations driving CAC.
Zihao Chen +4 more
wiley +1 more source
The Plant Journal, Volume 120, Issue 4, Page 1410-1420, November 2024.SUMMARY Genes of the family PHOSPHATIDYLETHANOLAMINE‐BINDING PROTEINS (PEBP) have been intensely studied in plants for their role in cell (re)programming and meristem differentiation. Recently, sporadic reports of the presence of a new type of PEBP in plants became available, highly similar to the YY‐PEBPs of prokaryotes.
Francesca Bellinazzo +10 more
wiley +1 more source
RKIP inhibits the malignant phenotypes of gastric cancer cells
Neoplasma, 2012 Raf kinase inhibitor protein (RKIP) is first identified as an interacting partner of Raf-1. RKIP expression is low or absent in several established cell lines derived from metastatic breast cancer, prostate cancer and melanoma cells. However, the functional role of RKIP in gastric cancer remains unclear.
X M, Zhang, H, Gu, L, Yan, G Y, Zhang
openaire +3 more sources
Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies
Reviews in Medical Virology, Volume 34, Issue 5, September 2024.ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit +1 more
wiley +1 more source
The Expression and Significance of RKIP in Lung Squamous Cell Carcinoma Tissues
Chinese Journal of Lung Cancer, 2011 Background and objective Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein (PEBP) family. RKIP is an endogenous inhibitor of the Raf-1-MEK1/2-ERK1/2 signaling pathway, NFkappaB signaling pathway and G protein ...
Haiyuan XU +6 more
doaj