Results 171 to 180 of about 56,719,399 (260)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

A 55-Word Story Narrative Medicine Workshop to Promote Reflective Practice Among Internal Medicine Residents. [PDF]

MedEdPORTAL
Gramelspacher AM, Man B, Bedell B, Blackie M.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Preclinical Assessment of Ezetimibe Combined with Curcumin in Colorectal Cancer Models. [PDF]

Drug Des Devel Ther
Ntwasa M, Malindisa S.
europepmc   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Contemporary Profile of Hybrid Nerve Sheath Tumors: Clinical, Anatomical, and Imaging Characteristics. [PDF]

Cancers (Basel)
Grübel N, Uerschels AK, Gembruch O, Wrede K, Schöffing F, Hohenhaus M, Scholz C, Hobitsch K, Kretschmer T, D'Souza S, Dengler NF, Wirtz CR, Deininger S, Osterloh A, Bremer J, Pedro MT, On Behalf Of The Peripheral Nerve Tumor Study Pntr Study Group.   +16 more
europepmc   +1 more source

16 Königin und Spielmann (Konrad Stekl) [25:14] (KUG KD 55)

Text: Bruno Ertler Komposition: Konrad Stekl Interpret*innen: Birgit Stöckler (Sopran), Maria Lerchenberger (Tenor), Petar Karagenov (Klavier), Christoph Hammer (Geige), Tom Sol (Sprecher), Harald Haslmayr (Moderator) Album: Bruno Ertler "Ewigkeiten" und

core  

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Impact of Ultrasound on the Physicochemical and Structural Properties of Gluten Protein During Controlled Thermal Treatment. [PDF]

Foods
Gu Z, Dai J, Ma Z, Yao H, Chen J, Zheng R, Xu X.   +6 more
europepmc   +1 more source

10 Es war I (Josef Wagnes) [​​​​​​​01:09] (KUG KD 55)

Text: Bruno Ertler Komposition: Josef Wagnes Interpret*innen: Birgit Stöckler (Sopran), Maria Lerchenberger (Tenor), Petar Karagenov (Klavier), Christoph Hammer (Geige), Tom Sol (Sprecher), Harald Haslmayr (Moderator) Album: Bruno Ertler "Ewigkeiten" und

core