Results 51 to 60 of about 2,212,261 (388)
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
The (–)-Borneol Effect on Addiction/Abstinence by Morphine in Mice
Drugs and Drug Candidates, 2023 Opioids such as morphine are the first choice in acute and chronic pain treatment. However, they lead to addiction. Several studies have searched (i) to find a molecule that can replace morphine use or (ii) to reduce its adverse effects.
Maurício Pires de Moura do Amaral +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Compounds, 2023 Brazilian flora are highly diverse and have great potential for research into new medicines of plant origin. Platonia insignis Mart. is a fruit tree from the Amazon region with several potential pharmacological applications already demonstrated.
Andressa Sabrina Guimarães Moura +10 more
doaj +1 more source
Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Demonstration of Mg2FeH6 as heat storage material at temperatures up to 550 °C
, 2016 The storage of heat at high temperatures, which can be used to generate electricity after sunset in concentrating solar power plants, is one of the most challenging technologies.
R. Urbanczyk +5 more
semanticscholar +1 more source
The550-au Mission: a critical discussion [PDF]
Monthly Notices of the Royal Astronomical Society, 2003 We have studied the science rationale, goals and requirements for a mission aimed at using the gravitational lensing from the Sun as a way of achieving high angular resolution and high signal amplification. We find that such a mission concept is plagued by several practical problems. Most severe are the effects due to the plasma in the solar atmosphere
Slava G. Turyshev, B-G Andersson
openaire +4 more sources
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Universal Scaling of Optimal Current Distribution in Transportation Networks
, 2009 Transportation networks are inevitably selected with reference to their global cost which depends on the strengths and the distribution of the embedded currents.
A. L. Barabási +12 more
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source