Results 51 to 60 of about 1,544,731 (337)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Crystal structure of (E)-N-phenyl-N′-[1-(thiophen-2-yl)ethylidene]formohydrazide

Acta Crystallographica Section E, 2014
In the title compound, C13H12N2OS, the planes of the thiophene and phenyl rings are nearly perpendicular to each other, making a dihedral angle of 86.42 (12)°.
C. S. Dileep, K. R. Raghavendra, N. K. Lokanath, K. Ajay Kumar, M. A. Sridhar   +4 more
doaj   +1 more source

Flexural behavior of two-span continuous prestressed concrete girders with highly eccentric external tendors [PDF]

, 2005
[Abstract]: It is generally known that the flexural strength of beams prestressed with external tendons is comparatively lower than that of members with internal bonded tendons.
Aravinthan, Thiru, Mutsuyoshi, Hiroshi, Witchukreangkrai, Eakarat   +2 more
core  

Surface enhancement of oxygen exchange and diffusion in the ionic conductor La2Mo2O9 [PDF]

, 2010
Isotopic surface oxygen exchange and its subsequent diffusion have been measured using secondary ion mass spectrometry in the fast ionic conductor La2Mo2O9.
Chater, R. J., Hagenhoff, B., Liu, J., Morris, R. J. H. (Richard J. H.), Skinner, S. J.   +4 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

XSS J00564+4548 and IGR J00234+6141 -- new cataclysmic variables from RXTE and INTEGRAL all sky surveys [PDF]

, 2006
We present the results of optical identification of two X-ray sources from RXTE and INTEGRAL all sky surveys: XSS J00564+4548 and IGR J00234+6141. Using the optical data from Russian-Turkish 1.5-m Telescope (RTT150) and SWIFT X-ray observations, we show ...
G. D. Schmidt, H. Ritter, I. F. Bikmaev, I. F. Bikmaev, J. H. M. M. Schmitt, J. M. Dickey, J. Patterson, M. G. Revnivtsev, M. Revnivtsev, N. Gehrels, N. R. Lomb, R. A. Burenin, R. A. Sunyaev, R. E. Williams, W. Voges   +14 more
core   +2 more sources

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Protective effect of rhizome extracts of the herb, vacha (Acorus calamus) against oxidative damage: An in vivo and in vitro study

Food Science and Human Wellness, 2016
The rhizome of Acorus calamus, an herb widely used in Indian system of medicine for many ailments including epilepsy, mental illness and rheumatism, was subjected to soxhlet extraction to elucidate antioxidant property of different solvent extracts using
M. Devaki, R. Nirupama, M. Nirupama, H.N. Yajurvedi   +3 more
doaj   +1 more source

Multi-targeted quinazolinone-Schiff's bases as potent bio-therapeutics

Results in Chemistry, 2020
Two series of quinazolinone derived Schiff's bases were synthesized and characterized by analytical and spectroscopic techniques. All the compounds were screened for their in vitro biological studies.
B.J. Ullas, K.P. Rakesh, J. Shivakumar, D. Channe Gowda, P.G. Chandrashekara   +4 more
doaj   +1 more source

Space Velocities of L- and T-type Dwarfs [PDF]

, 2007
(Abridged) We have obtained radial velocities of a sample of 18 ultracool dwarfs (M6.5-T8) using high-resolution, near-infrared spectra obtained with NIRSPEC and the Keck II telescope.
Chen B., Delfosse X., E. L. Martin, H. Bouy, Hawkins M. R. S., Haywood M., Haywood M., Kharchenko N. V., M. R. Zapatero Osorio, Martin E. L., Mayor M., Perryman M. A. C., Phan-Bao N., Potter D., R. Deshpande, R. J. Wainscoat, V. J. S. Bejar, Wielen R.   +17 more
core   +3 more sources