Results 121 to 130 of about 470,581 (264)

MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by progressive spasticity and lower limb weakness. The most common forms of autosomal dominant HSP are caused by pathogenic variants in SPAST (SPG4 or HSP‐SPAST), ATL1 (SPG3A or HSP‐ATL1), and REEP1 (SPG31 or HSP‐REEP1).
Ce Kang   +24 more
wiley   +1 more source

Development and Validation of a Questionnaire‐Based Model for Households With Multiple Helicobacter pylori Infections: A Family‐Based Screening Strategy

open access: yesMed Research, EarlyView.
This study developed and externally validated a questionnaire‐based household risk model to identify families with multiple Helicobacter pylori infections. Using only noninvasive, readily available household information, the model showed good discrimination and enabled a family‐based screening strategy that substantially improved detection efficiency ...
Yifan Qiu   +9 more
wiley   +1 more source

Revisiting the Association Between Calcium Channel Blockers and Parkinson's Disease in the E3N Cohort

open access: yesMovement Disorders, EarlyView.
Abstract Background Previous studies on calcium channel blockers (CCBs) and Parkinson's disease (PD) risk reached conflicting conclusions. Objectives We examined the relationship between CCBs and PD in the E3N cohort of French women followed for 15 years (2004–2018), while taking into account the potential for reverse causation.
Emilie Moutard   +9 more
wiley   +1 more source

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay   +3 more
wiley   +1 more source

Weight Loss Intentionality and Strategies in Urinary Incontinence

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Urinary incontinence (UI)−including stress (SUI), urge (UUI), and mixed (MUI) subtypes−is associated with obesity, and weight loss is commonly recommended for intervention. However, the comparative effects of intentionality and weight loss strategies on UI severity remain poorly defined.
Eric S. Chai   +7 more
wiley   +1 more source

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