Results 41 to 50 of about 628,388 (295)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Attention on the Preambles: Sensing With mmWave CSI

IEEE Open Journal of the Communications Society
The ubiquitous availability of wireless networks and devices provides a unique opportunity to leverage the corresponding communication signals to enable wireless sensing applications. In this article, we develop a new framework for environment sensing by
Tatsuya Kikuzuki, Mahdi Boloursaz Mashhadi, Yi Ma, Rahim Tafazolli   +3 more
doaj   +1 more source

Energy Beamforming for MIMO WIPT Relaying With Arbitrary Correlation

IEEE Access, 2018
This paper investigates the negative impact of spatial fading correlation in multiple-input multiple-output relaying systems on the performance of energy beamforming.
Ahmed Almradi, Pei Xiao
doaj   +1 more source

DSEP Fulcrum: Dynamic Sparsity and Expansion Packets for Fulcrum Network Coding

IEEE Access, 2020
Fulcrum coding combines a high-field outer Random Linear Network Coding (RLNC) that generates outer coding expansion packets with a small-field inner RLNC that combines the source packets and the outer coding expansion packets.
Vu Nguyen, Elif Tasdemir, Giang T. Nguyen, Daniel E. Lucani, Frank H. P. Fitzek, Martin Reisslein   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Security of Topology Discovery Service in SDN: Vulnerabilities and Countermeasures

IEEE Open Journal of the Communications Society
Software-Defined Network (SDN) controller needs comprehensive visibility of the whole network to provide effective routing and forwarding decisions in the data layer.
Sanaz Soltani, Ali Amanlou, Mohammad Shojafar, Rahim Tafazolli   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Optimizing Near-Field XL-MIMO Communications: Advanced Feedback Framework for CSI

IEEE Access
With the successful deployment of fifth-generation (5G) systems, both industry and academia anticipate the evolution of 6G systems to meet future data-intensive needs.
Sourav Mukherjee, Mohammed Saquib Khan, Ashok Kumar Reddy Chavva   +2 more
doaj   +1 more source