Results 1 to 10 of about 821,672 (219)
GLP-1 receptor agonists can reverse immunosuppression-induced beta-cell dysfunction [PDF]
CellR4, 2020 It is well known that some of the agents commonly used during immunosuppressive (IS) therapy after solid organ transplantation can contribute to beta cell dysfunction and result in diabetes mellitus in the transplant recipient.
S. Bertera +5 more
doaj +1 more source
Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice
Frontiers in Endocrinology, 2021 A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans,
Yesica Garciafigueroa +6 more
doaj +1 more source
Human islet isolation: status and future considerations* [PDF]
CellR4, 2019 Autologous human islet transplantation to mitigate or prevent surgically induced diabetes after total pancreatectomy for the relief of chronic pancreatitisinduced pain was pioneered in the late 1970s.
R. Bottino +4 more
doaj +1 more source
Cardiovascular Diabetology, 2022 Background Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2 diabetes (T2D).
Brett E. Phillips +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic activity is an attractive therapeutic approach as it results in multiple and ...
Brett E. Phillips +10 more
doaj +1 more source
Management of congenital dysfibrinogenemia in pregnancy: A challenging patient case
Research and Practice in Thrombosis and Haemostasis, 2021 Afibrinogenemia and congenital dysfibrinogenemia (CD) are rare conditions with limited information available for appropriate management. Previous case reports have demonstrated the safe and efficacious use of fibrinogen replacement therapy (FRT) as a ...
Megan Langer +5 more
doaj +1 more source
Human Neural Stem Cells for Cell-Based Medicinal Products
Cells, 2021 Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders.
Beatriz Fernandez-Muñoz +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in humoral immunity. However, the molecular mechanism underlying generation of TFH cells is incompletely understood.
Lingtao Yang +12 more
doaj +1 more source
Frontiers in Immunology, 2018 Dendritic cells (DC) are important in the onset and severity of inflammatory bowel disease (IBD). Tolerogenic DC induce T-cells to become therapeutic Foxp3+ regulatory T-cells (Tregs).
Carl Engman +6 more
doaj +1 more source
Nature Communications, 2021 Innate immune cells respond to a number of environmental cues including TLR signalling. Here the authors implicate mechanical sensor Piezo1 in the TLR4 mediated host response to bacterial infection and implicate it in the enhancement of macrophage ...
Jing Geng +15 more
doaj +1 more source