Results 21 to 30 of about 777,473 (267)

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Nature Communications, 2021
Innate immune cells respond to a number of environmental cues including TLR signalling. Here the authors implicate mechanical sensor Piezo1 in the TLR4 mediated host response to bacterial infection and implicate it in the enhancement of macrophage ...
Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou   +15 more
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An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

Nature Communications, 2020
Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with
Yuanyuan Jiang, Jun Wei, Huiting Cui, Chuanyuan Liu, Yuan Zhi, ZhengZheng Jiang, Zhenkui Li, Shaoneng Li, Zhenke Yang, Xu Wang, Pengge Qian, Cui Zhang, Chuanqi Zhong, Xin-zhuan Su, Jing Yuan   +14 more
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A Case of Vancomycin-Induced Severe Immune Thrombocytopenia

Hematology Reports, 2023
A male in his 60s presented with left lower extremity fractures following a vehicle accident. Hemoglobin, initially, was 12.4 mmol/L, and platelet count was 235 k/mcl.
Shivani Shah, Ryan Sweeney, Maitreyee Rai, Deep Shah   +3 more
doaj   +1 more source

Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice

Frontiers in Medicine, 2021
Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to long-term islet function, and outcomes are not always successful.
Suzanne Bertera, Michael F. Knoll, Carmela Knoll, Hidetaka Hara, Erin A. Kimbrel, Nickolas A. Kouris, Robert Lanza, Brett E. Philips, Yesica Garciafigueroa, Nick Giannoukakis, Nick Giannoukakis, David K. C. Cooper, Massimo Trucco, Massimo Trucco, Rita Bottino   +14 more
doaj   +1 more source

The Future of Islet Transplantation Is Now

Frontiers in Medicine, 2018
Milestones in the history of diabetes therapy include the discovery of insulin and successful methods of beta cell replacement including whole pancreas and islet cell transplantation options.
Rita Bottino, Rita Bottino, Rita Bottino, Michael F. Knoll, Carmela A. Knoll, Suzanne Bertera, Massimo M. Trucco, Massimo M. Trucco, Massimo M. Trucco   +8 more
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A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC

EMBO Molecular Medicine, 2021
More than 60% of nonsmall cell lung cancer (NSCLC) patients show a positive response to the first ALK inhibitor, crizotinib, which has been used as the standard treatment for newly diagnosed patients with ALK rearrangement.
Yue Lu, Zhenzhen Fan, Su‐Jie Zhu, Xiaoxing Huang, Zhongji Zhuang, Yunzhan Li, Zhou Deng, Lei Gao, Xuehui Hong, Ting Zhang, Li Li, Xihuan Sun, Wei Huang, Jingfang Zhang, Yan Liu, Baoding Zhang, Jie Jiang, Fu Gui, Zheng Wang, Qiyuan Li, Siyang Song, Xin Huang, Qiao Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Cai‐Hong Yun, Liang Chen, Xianming Deng   +28 more
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RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Nature Communications, 2017
Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death.
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu, Jiahuai Han   +10 more
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c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

Nature Communications, 2017
The protein tyrosine kinase c-Src is a renowned proto-oncogene with pleiotropic effects. Here, the authors show that c-Src induces the metabolic reprogramming of cancer cells by phosphorylating hexokinases HK1 and HK2, which in turns lead to increased HK
Jia Zhang, Suili Wang, Bin Jiang, Lihong Huang, Zhiliang Ji, Xiaotong Li, Huamin Zhou, Aidong Han, Ai Chen, Yanan Wu, Huanhuan Ma, Wentao Zhao, Qingwen Zhao, Changchuan Xie, Xiaoyan Sun, Yanming Zhou, Huiying Huang, Muhammad Suleman, Furong Lin, Lin Zhou, Fang Tian, Meijun Jin, Yana Cai, Nan Zhang, Qinxi Li   +24 more
doaj   +1 more source

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy

Frontiers in Immunology, 2019
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards.
Brett Eugene Phillips, Yesica Garciafigueroa, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
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Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition

Molecules, 2021
Peroxisome proliferator-activated receptors (PPARs) play crucial roles in glucose and lipid metabolism and inflammation. Sanguinarine is a natural product that is isolated from Sanguinaria Canadensis, a potential therapeutic agent for intervention in ...
Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li   +5 more
doaj   +1 more source