Results 31 to 40 of about 6,348,214 (302)

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Nature Communications, 2017
Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death.
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu, Jiahuai Han   +10 more
doaj   +1 more source

Non-Direct Encoding Method Based on Cellular Automata to Design Neural Network Architectures [PDF]

, 2005
Architecture design is a fundamental step in the successful application of Feed forward Neural Networks. In most cases a large number of neural networks architectures suitable to solve a problem exist and the architecture design is, unfortunately, still ...
Gutiérrez Sánchez, Germán, Molina López, José Manuel, Galván, Inés M., Sanchis de Miguel, María Araceli, Isasi, Pedro   +4 more
core   +1 more source

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

Nature Communications, 2017
The protein tyrosine kinase c-Src is a renowned proto-oncogene with pleiotropic effects. Here, the authors show that c-Src induces the metabolic reprogramming of cancer cells by phosphorylating hexokinases HK1 and HK2, which in turns lead to increased HK
Jia Zhang, Suili Wang, Bin Jiang, Lihong Huang, Zhiliang Ji, Xiaotong Li, Huamin Zhou, Aidong Han, Ai Chen, Yanan Wu, Huanhuan Ma, Wentao Zhao, Qingwen Zhao, Changchuan Xie, Xiaoyan Sun, Yanming Zhou, Huiying Huang, Muhammad Suleman, Furong Lin, Lin Zhou, Fang Tian, Meijun Jin, Yana Cai, Nan Zhang, Qinxi Li   +24 more
doaj   +1 more source

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy

Frontiers in Immunology, 2019
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards.
Brett Eugene Phillips, Yesica Garciafigueroa, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
doaj   +1 more source

Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition

Molecules, 2021
Peroxisome proliferator-activated receptors (PPARs) play crucial roles in glucose and lipid metabolism and inflammation. Sanguinarine is a natural product that is isolated from Sanguinaria Canadensis, a potential therapeutic agent for intervention in ...
Siyu Tian, Rui Wang, Shuming Chen, Jialing He, Weili Zheng, Yong Li   +5 more
doaj   +1 more source

On the security of software-defined next-generation cellular networks [PDF]

, 2016
In the recent years, mobile cellular networks are ndergoing fundamental changes and many established concepts are being revisited. Future 5G network architectures will be designed to employ a wide range of new and emerging technologies such as Software ...
Moscholios, Ioannis, Logothetis, Michael, Vassilakis, Vassilios, Alzahrani, Bander   +3 more
core   +3 more sources

Microbial synthesis of 4-hydroxybenzoic acid from renewable feedstocks

Food Chemistry: Molecular Sciences, 2021
4-Hydroxybenzoic acid (4HBA) and its esterified forms can be used as preservatives in the pharmaceutical and food industries. Here, we reported the establishment of a coenzyme-A (CoA) free multi-enzyme cascade in Escherichia coli to utilize biobased L ...
Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan   +4 more
doaj   +1 more source

Delayed diagnosis of POEMS syndrome, how AI tools can enhance diagnostic accuracy

European Journal of Case Reports in Internal Medicine
Polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes (POEMS) syndrome is a rare multisystem disorder often misdiagnosed due to its wide-ranging manifestations and clinical overlap with common medical conditions.
Max Jin, Sowbharnika Arivazhagan, Prerna Mewawalla, Santhosh Sadashiv, Arjun Lakshman   +4 more
doaj   +1 more source

A 31-plex panel for high-dimensional single-cell analysis of murine preclinical models of solid tumors by imaging mass cytometry

Frontiers in Immunology, 2023
Currently, the study of resistance mechanisms and disease progression in cancer relies on the capacity to analyze tumors as a complex ecosystem of healthy and malignant cells.
Yaël Glasson, Yaël Glasson, Laure-Agnès Chépeaux, Anne-Sophie Dumé, Philippe Jay, Nelly Pirot, Nelly Pirot, Nathalie Bonnefoy, Nathalie Bonnefoy, Henri-Alexandre Michaud, Henri-Alexandre Michaud   +10 more
doaj   +1 more source

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Nature Communications, 2019
Immune cells produce reactive oxygen species (ROS) to eliminate pathogens, but cell-spontaneous death and ageing may also be induced. Here the authors show that, upon sensing ROS, Mst1/2 kinases modulate the activity of Nrf2 transcription factor and ...
Ping Wang, Jing Geng, Jiahui Gao, Hao Zhao, Junhong Li, Yiran Shi, Bingying Yang, Chen Xiao, Yueyue Linghu, Xiufeng Sun, Xin Chen, Lixin Hong, Funiu Qin, Xun Li, Jau-Song Yu, Han You, Zengqiang Yuan, Dawang Zhou, Randy L. Johnson, Lanfen Chen   +19 more
doaj   +1 more source