Results 61 to 70 of about 196,289 (295)

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

Side‐Chains Engineered Self‐Assembly of Ortho‐Benzodipyrrole‐Based Acceptors: Comprehensive Exploration of Structure‐Interface‐Photovoltaics Correlations

Advanced Functional Materials, EarlyView.
The side‐chain configuration in the bay region of C‐shaped ortho‐benzodipyrrole‐based non‐fullerene acceptors plays a crucial role in their self‐assembly, single‐crystal structures, and optoelectronic properties. The closely correlated molecular structure and performance underscore the importance of minimizing A–A self‐aggregation and enhancing D–A ...
Yung‐Jing Xue, Chen‐Yu Chang, Chieh‐Ming Hung, Chi‐Chun Tseng, Je‐Wei Chang, Chun‐Jen Su, Chia‐Lin Tsai, Han‐Cheng Lu, Kuo‐Hsiu Huang, Kuei‐Yu Tai, Chien‐Yi Ku, Chia‐Shing Wu, Su‐Ying Chien, Shang‐Da Yang, Bing‐Huang Jiang, Chih‐Ping Chen, Pi‐Tai Chou, U‐Ser Jeng, Yen‐Ju Cheng   +18 more
wiley   +1 more source

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

Advanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +4 more
wiley   +1 more source

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

Discovery of Novel Inhibitors for Nek6 Protein through Homology Model Assisted Structure Based Virtual Screening and Molecular Docking Approaches

The Scientific World Journal, 2014
Nek6 is a member of the NIMA (never in mitosis, gene A)-related serine/threonine kinase family that plays an important role in the initiation of mitotic cell cycle progression.
P. Srinivasan, P. Chella Perumal, A. Sudha   +2 more
doaj   +1 more source

Surface Adsorption Properties and Layer Structures of Homogeneous Polyoxyethylene-Type Nonionic Surfactants in Quaternary-Ammonium-Salt-Type Amphiphilic Gemini Ionic Liquids with Oxygen- or Nitrogen-Containing Spacers

Molecules, 2020
The amphiphilic ionic liquids containing an alkyl chain in molecules form nano-structure in the bulk, although they also show surface activity and form aggregates in aqueous solutions.
Risa Kawai, Maiko Niki, Shiho Yada, Tomokazu Yoshimura   +3 more
doaj   +1 more source

Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording

Advanced Functional Materials, EarlyView.
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh, Kwangjun Kim, Chaesung Kim, Minju Kim, Minwook Kim, Sangjun Sim, Jongbaeg Kim, Jong G. Ok, Maesoon Im   +8 more
wiley   +1 more source

The Anti-Aging Potential of Extracts from Chaenomeles sinensis

Cosmetics, 2019
The Chaenomeles sinensis fruit is used as an effective antitussive agent, analgesic, and diuretic in traditional Chinese medicine. It has been reported that C. sinensis fruit extracts have antimicrobial and anti-inflammatory effects.
Shintaro Itoh, Manami Yamaguchi, Keita Shigeyama, Ikuyo Sakaguchi   +3 more
doaj   +1 more source

Additive‐Driven Phase Control for Stable and Efficient CsPbI₃ Solar Cells Via Ambient Low‐Temperature Processing

Advanced Functional Materials, EarlyView.
CsPbI₃ perovskite solar cells face stability issues due to high annealing temperatures and moisture. Butylammonium acetate (BAAc) enables stable phase formation at 160°C in ambient laboratory conditions, enhancing efficiency and stability, achieving 18.6% PCE, and maintaining over 81% efficiency after 1,000 hours of maximum power point tracking under 1
Narendra Pai, Aaron Seeber, Wen Liang Tan, Luke J. Sutherland, Chris Easton, Wenqi Yan, Yogesh Gulia, Yesim Gozukara, Jueng‐Eun Kim, Mei Gao, Dechan Angmo   +10 more
wiley   +1 more source