Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models [PDF]
BiomoleculesSmith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC).
Zeljka Korade +5 more
doaj +2 more sources
DHCR7: from sterol biosynthesis to oncogenic role in colorectal cancer [PDF]
PeerJObjective 7-Dehydrocholesterol reductase (DHCR7) is an enzyme that plays a crucial regulatory role in sterol biosynthesis and has been implicated in tumorigenesis and progression.
Chuan Zhou +8 more
doaj +3 more sources
Use of cholic acid in Smith-Lemli-Opitz syndrome (SLOS): real-world patient outcomes [PDF]
Orphanet Journal of Rare DiseasesBackground Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic pathogenic variants in DHCR7, which encodes the enzyme 7-dehydrocholesterol reductase (DHCR7).
Edwin Ferren +10 more
doaj +2 more sources
Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
Biomolecules, 2022 Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ).
Marta Balog +4 more
doaj +1 more source
International Journal of Plant & Soil Science, 2023 Tomatoes are the most popular vegetable crop worldwide and contain many health-promoting compounds. Most foods contain very little amount of vitamin D, and plants are very poor sources in the production of vitamin D.
Poleboina Venkata Diwakar +5 more
semanticscholar +1 more source
Diatoms synthesize sterols by inclusion of animal and fungal genes in the plant pathway [PDF]
, 2020 Diatoms are ubiquitous microalgae that have developed remarkable metabolic plasticity and gene diversification. Here we report the first elucidation of the complete biosynthesis of sterols in the lineage.
, Angela +7 more
core +1 more source
Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production
Biomolecules, 2021 24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj +1 more source
Mapping molluscan endocrinology: a systematic and critical appraisal. [PDF]
Biol Rev Camb Philos SocABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Panagiotidis K +3 more
europepmc +2 more sources
Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]
, 2008 Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R. +8 more
core +2 more sources
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway. [PDF]
Cancer SciIn pancreatic cancer, elevated DHCR7 expression enhances cholesterol biosynthesis and then activates the PI3K‐Akt signaling pathway, promoting epithelial‐mesenchymal transition (EMT) and facilitating liver metastasis. Knockdown of DHCR7 suppresses tumor proliferation, invasion, and metastatic colonization in vivo and in vitro, highlighting its role as ...
Xie Y +7 more
europepmc +2 more sources