Results 1 to 10 of about 795,651 (284)

Clinical Impact of a Pharmacist-Driven Prospective Audit with Intervention and Feedback on the Treatment of Patients with Bloodstream Infection

Antibiotics, 2022
Evidence for the utility of pharmacist-driven antimicrobial stewardship programs remains limited. This study aimed to evaluate the usefulness of our institutional pharmacist-driven prospective audit with intervention and feedback (PAF) on the treatment ...
Naoto Okada, Momoyo Azuma, Kaito Tsujinaka, Akane Abe, Mari Takahashi, Yumiko Yano, Masami Sato, Takahiro Shibata, Mitsuhiro Goda, Keisuke Ishizawa   +9 more
doaj   +1 more source

Study of dynamics of the process $$e^+e^-\rightarrow \pi ^+\pi ^-\pi ^0$$ e + e - → π + π - π 0 in the energy range 1.15–2.00 GeV

European Physical Journal C: Particles and Fields, 2020
The dynamics of the process $$ e^+e^- \rightarrow \pi ^+\pi ^-\pi ^0 $$ e + e - → π + π - π 0 is studied in the energy region from 1.15 to 2.00 GeV using data accumulated with the SND detector at the VEPP-2000 $$e^+e^-$$ e + e - collider. The Dalitz plot
M. N. Achasov, A. Yu. Barnyakov, A. A. Baykov, K. I. Beloborodov, A. V. Berdyugin, D. E. Berkaev, A. G. Bogdanchikov, A. A. Botov, T. V. Dimova, V. P. Druzhinin, V. B. Golubev, A. N. Kirpotin, L. V. Kardapoltsev, A. S. Kasaev, A. G. Kharlamov, I. A. Koop, A. A. Korol, D. P. Kovrizhin, A. S. Kupich, K. A. Martin, N. A. Melnikova, N. Yu. Muchnoy, A. E. Obrazovsky, E. V. Pakhtusova, K. V. Pugachev, D. V. Rabusov, Yu. A. Rogovsky, Y. S. Savchenko, A. I. Senchenko, S. I. Serednyakov, D. N. Shatilov, Yu. M. Shatunov, D. A. Shtol, D. B. Shwartz, Z. K. Silagadze, I. K. Surin, M. V. Timoshenko, Yu. V. Usov, V. N. Zhabin, V. V. Zhulanov   +39 more
doaj   +1 more source

miR-770–5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1

Ecotoxicology and Environmental Safety, 2021
Silicosis is a devastating interstitial lung disease arising from long-term exposure to inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced fibrotic lesion. Emerging evidence has indicated that the dysregulation
Jiali Yuan, Ping Li, Honghong Pan, Qi Xu, Tiantian Xu, Yan Li, Dong Wei, Yiqun Mo, Qunwei Zhang, Jingyu Chen, Chunhui Ni   +10 more
doaj   +1 more source

MicroRNA-770 affects proliferation and cell cycle transition by directly targeting CDK8 in glioma

Cancer Cell International, 2018
Background MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resistance.
Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu, Ling-yu Zhao   +10 more
doaj   +1 more source

Involvement of a Rarely Used Splicing SD2b Site in the Regulation of HIV-1 vif mRNA Production as Revealed by a Growth-Adaptive Mutation

Viruses, 2023
We have previously reported an HIV-1 mutant designated NL-Y226tac that expresses Vif at an ultra-low level, being replication-defective in high-APOBEC3G cells, such as H9.
Takaaki Koma, Naoya Doi, Bao Quoc Le, Tomoyuki Kondo, Mitsuki Ishizue, Chiaki Tokaji, Chizuko Tsukada, Akio Adachi, Masako Nomaguchi   +8 more
doaj   +1 more source

Drug Discovery for Overcoming Chronic Kidney Disease (CKD): Development of Drugs on Endothelial Cell Protection for Overcoming CKD

Journal of Pharmacological Sciences, 2009
Chronic kidney disease (CKD) is becoming a major public health problem worldwide. It is important to protect endothelial function in CKD treatment because injury of the endothelium is a critical event for the generation and progression of CKD.
Keisuke Ishizawa, Kunihisa Yamaguchi, Yuya Horinouchi, Yayoi Fukuhara, Soichiro Tajima, Shuichi Hamano, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki   +8 more
doaj   +1 more source

MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy [PDF]

Brazilian Journal of Medical and Biological Research
Diabetic nephropathy (DN) has been identified as the major cause of end-stage renal disease (ESRD) in most developed countries. MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F ...
Juanjuan Guo, Jie Han, Jieying Liu, Shaoli Wang   +3 more
doaj   +2 more sources

Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia

Life, 2021
Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment.
Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto, Yasushi Takagi   +10 more
doaj   +1 more source

Pharmacology in Health Food: Metabolism of Quercetin In Vivo and Its Protective Effect Against Arteriosclerosis

Journal of Pharmacological Sciences, 2011
Quercetin, a member of the bioflavonoids family, has been proposed to have antiatherogenic, anti-inflammatory, and anti-hypertensive properties leading to the beneficial effects against cardiovascular diseases. It was recently demonstrated that quercetin
Keisuke Ishizawa, Masanori Yoshizumi, Yoshichika Kawai, Junji Terao, Yoshitaka Kihira, Yasumasa Ikeda, Shuhei Tomita, Kazuo Minakuchi, Koichiro Tsuchiya, Toshiaki Tamaki   +9 more
doaj   +1 more source

Effects of concentration of CRISPR/Cas9 components on genetic mosaicism in cytoplasmic microinjected porcine embryos

The Journal of Reproduction and Development, 2019
Cytoplasmic microinjection (CI) of the CRISPR/Cas9 system enabled the induction of site-specific mutations in porcine zygotes and resulting pigs. However, mosaicism is a serious problem for genetically modified pigs. In the present study, we investigated
Fuminori TANIHARA, Maki HIRATA, Nhien Thi NGUYEN, Quynh Anh LE, Takayuki HIRANO, Takeshige OTOI   +5 more
doaj   +1 more source