Results 21 to 30 of about 795,651 (284)
Design of Prodrugs to Enhance Colonic Absorption by Increasing Lipophilicity and Blocking Ionization
Pharmaceuticals, 2014 Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties.
Rebecca Nofsinger +17 more
doaj +1 more source
Clinically Feasible and Accurate View Classification of Echocardiographic Images Using Deep Learning
Biomolecules, 2020 A proper echocardiographic study requires several video clips recorded from different acquisition angles for observation of the complex cardiac anatomy. However, these video clips are not necessarily labeled in a database.
Kenya Kusunose +5 more
doaj +1 more source
Lower expression of miR-770-5p is associated with tumor samples.
, 2019 Expression level of miR-770-5p was downregulated in tumor samples compared to normal samples (One-way ANOVA ...
Bala Gur Dedeoglu (739961) +2 more
core +1 more source
BiomoleculesVX-770 is a small-molecule CFTR potentiator that is highly efficacious in individuals with cystic fibrosis caused by mutations in CFTR that result in a defect in channel gating.
Heidi J. Nick +2 more
doaj +1 more source
Use of Echocardiography and Heart Failure In-Hospital Mortality from Registry Data in Japan
Journal of Cardiovascular Development and Disease, 2021 Background: Echocardiography requires a high degree of skill on the part of the examiner, and the skill may be more improved in larger volume centers.
Kenya Kusunose +13 more
doaj +1 more source
miR-770-5p regulates motility and invasion in BT-474 and SK-BR-3 cells.
, 2019 (a) The rate of motility was assessed by wound-healing assay. Wound closure was observed in scrambled control-transfected cells in a time-dependent manner while miR-770-5p mimic transfected cells lost their motility (n = 2, *p(b) Cell invasion analysis ...
Bala Gur Dedeoglu (739961) +2 more
core +1 more source
Journal of Pharmacological Sciences, 2009 Many epidemiologic studies have reported that dietary flavonoids provide protection against cardiovascular disease. Quercetin, a member of the bioflavonoids family, has been proposed to have anti-inflammatory, anti-atherogenic, and anti-hypertensive ...
Keisuke Ishizawa +9 more
doaj +1 more source
The Cerebellum Is a Common Key for Visuospatial Execution and Attention in Parkinson’s Disease
Diagnostics, 2021 Cognitive decline affects the clinical course in patients with Parkinson’s disease (PD) and contributes to a poor prognosis. However, little is known about the underlying network-level abnormalities associated with each cognitive domain.
Wataru Sako +7 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source