Results 141 to 150 of about 1,780 (186)
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Neuroscience Letters, 1985
The effect of the selective 5-hydroxytryptamine (5-HT-1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on nociception and morphine analgesia was tested with the tail-flick method in mice. 8-OH-DPAT (0.06-1.0 mg/kg) had no apparent effect on the general behavior of the animals and did not change their reactivity to stimulation ...
Odd-Geir Berge +2 more
exaly +3 more sources
The effect of the selective 5-hydroxytryptamine (5-HT-1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on nociception and morphine analgesia was tested with the tail-flick method in mice. 8-OH-DPAT (0.06-1.0 mg/kg) had no apparent effect on the general behavior of the animals and did not change their reactivity to stimulation ...
Odd-Geir Berge +2 more
exaly +3 more sources
European Journal of Pharmacology, 1984
The putative 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) produced in rats an increase in the number of shocks accepted in a modified Vogel's conflict test design. Subchronic pretreatment with p-chlorophenylalanine (PCPA) similarly caused release of the punished behavior.
Jorgen A Engel +2 more
exaly +3 more sources
The putative 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) produced in rats an increase in the number of shocks accepted in a modified Vogel's conflict test design. Subchronic pretreatment with p-chlorophenylalanine (PCPA) similarly caused release of the punished behavior.
Jorgen A Engel +2 more
exaly +3 more sources
European Journal of Pharmacology, 1999
The effects of intra-amygdala injection of midazolam (20 nmol) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 8 and 16 nmol) were investigated in rats submitted to the elevated T-maze, a new animal model of anxiety. This test allows the measurement, in the same rat, of conditioned and unconditioned fear/anxiety responses.
Helio Zangrossi +2 more
exaly +3 more sources
The effects of intra-amygdala injection of midazolam (20 nmol) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 8 and 16 nmol) were investigated in rats submitted to the elevated T-maze, a new animal model of anxiety. This test allows the measurement, in the same rat, of conditioned and unconditioned fear/anxiety responses.
Helio Zangrossi +2 more
exaly +3 more sources
European Journal of Pharmacology, 1992
The effects of various subcutaneous doses (30, 100 and 300 micrograms/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)1A receptor agonist, were studied on the performance of rats in a one-trial passive avoidance task. When administered 30 min before the training trial and the retention test, 8-OH-DPAT significantly reduced ...
Rosario Samanin, M Carli, R Samanin
exaly +3 more sources
The effects of various subcutaneous doses (30, 100 and 300 micrograms/kg) of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a serotonin (5-HT)1A receptor agonist, were studied on the performance of rats in a one-trial passive avoidance task. When administered 30 min before the training trial and the retention test, 8-OH-DPAT significantly reduced ...
Rosario Samanin, M Carli, R Samanin
exaly +3 more sources
Effect of 8-hydroxy-2-(di-n-propylamino) tetralin on rat prolactin secretion
Journal of Neural Transmission, 19848-OH- DPAT (8-hydroxy-2-[di-n-propylamino] tetralin) is a novel aminotetralin derivative which has been proposed to be a serotonin (5-HT) agonist devoid of dopamine agonist effects. We now report that the administration of 8-OH- DPAT , like known 5-HT agonists, produced a rapid elevation of serum prolactin concentrations in male rats.
M, Simonovic +2 more
openaire +2 more sources
Pharmacokinetic and pharmacodynamic studies of (R)-8-hydroxy-2-(di-n-propylamino)tetralin in the rat
European Neuropsychopharmacology, 1997Racemic 8-OH-DPAT, (R,S)-8-hydroxy-2-(di-n-propylamino)tetralin, has become the prototype 5-HT1A receptor agonist. The enantiomers of 8-OH-DPAT have similar affinities to the 5-HT1A receptor, but the (R)-enantiomer is a full agonist, whereas the (S)-enantiomer is a partial agonist.
H, Yu, T, Lewander
openaire +2 more sources
The behavioural effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in mice
European Journal of Pharmacology, 1988The effects of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on the behaviour of mice were studied. 8-OH-DPAT given i.v. in doses greater than 1 mg/kg induced the distinct 5-HT syndrome, including head weaving, hindlimb abduction, forepaw treading and tremor. The 8-OH-DPAT-induced behaviour was not affected by the 5-HT
J, Yamada, Y, Sugimoto, K, Horisaka
openaire +2 more sources
A New Synthesis of 8-Hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT)
Synthetic Communications, 1992Abstract A new synthesis method for 8-OH-DPAT, a specific agonist at the 5-HT1A serotonin receptor, is described. It employs the Curtius degradation of a tetralin carboxylic acid easily prepared from (2-methoxy benzyl) succinic acid by Friedel-Crafts cyclisation.
Michel Langlois, Florence Gaudy
openaire +1 more source
Life Sciences, 1990
Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from ...
Li, ETS, Luo, S, Ransom, T
openaire +4 more sources
Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from ...
Li, ETS, Luo, S, Ransom, T
openaire +4 more sources