Results 171 to 180 of about 1,780 (186)
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Neurochemical effects of 8-hydroxy-2-di-n-propylamino tetralin in rats treated with haloperidol.
Pakistan journal of pharmaceutical sciences, 2006In view of a possible role of presynaptic serotonin (5-hydroxytryptamine, 5-HT) receptors in the precipitation of extrapyramidal side effects (EPS), the present study was designed to investigate the neurochemical effects of a selective 5-HT1A ligand, 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT) in rats following single (5 mg/kg) and repeated ...
Erum, Shireen +4 more
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Journal of Medicinal Chemistry, 1988
A number of stereochemically well defined C3-methylated derivatives of the potent 5-hydroxytryptamine (5-HT) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) have been synthesized, and their stereochemical characteristics have been studies by use of NMR spectroscopy, X-ray crystallography, and molecular mechanics calculations.
C, Mellin +8 more
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A number of stereochemically well defined C3-methylated derivatives of the potent 5-hydroxytryptamine (5-HT) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) have been synthesized, and their stereochemical characteristics have been studies by use of NMR spectroscopy, X-ray crystallography, and molecular mechanics calculations.
C, Mellin +8 more
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European Journal of Pharmacology, 1995
In different animal species, microinjections of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the nucleus tractus solitarii failed to alter arterial blood pressure and sympathetic nerve activity; however, the cardiovascular effects (hypotension, bradycardia, reduction in sympathetic nerve activity) of intravenous ...
C, Vayssettes-Courchay +3 more
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In different animal species, microinjections of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the nucleus tractus solitarii failed to alter arterial blood pressure and sympathetic nerve activity; however, the cardiovascular effects (hypotension, bradycardia, reduction in sympathetic nerve activity) of intravenous ...
C, Vayssettes-Courchay +3 more
openaire +2 more sources
The Journal of Pharmacology and Experimental Therapeutics, 2006
The mechanism of action by which 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) facilitates ejaculation in conscious rats is not clearly established. The serotonin (5-HT) 1A agonist 8-OH-DPAT may actually act on cerebral dopaminergic receptors to exert its proejaculatory effect.
Pierre, Clément +4 more
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The mechanism of action by which 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT) facilitates ejaculation in conscious rats is not clearly established. The serotonin (5-HT) 1A agonist 8-OH-DPAT may actually act on cerebral dopaminergic receptors to exert its proejaculatory effect.
Pierre, Clément +4 more
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European Journal of Pharmacology, 1993
Cardiovascular neurones with sympathetic nerve and cardiac related activity have been detected in the lateral tegmental field and have been classified depending on their response to baroreceptor activation. Baroreflex activation decreased and increased the firing rate of sympatho-excitatory neurones and sympatho-inhibitory neurones respectively ...
C, Vayssettes-Courchay +3 more
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Cardiovascular neurones with sympathetic nerve and cardiac related activity have been detected in the lateral tegmental field and have been classified depending on their response to baroreceptor activation. Baroreflex activation decreased and increased the firing rate of sympatho-excitatory neurones and sympatho-inhibitory neurones respectively ...
C, Vayssettes-Courchay +3 more
openaire +2 more sources
Neuroscience Letters, 1985
The effects of the serotonin (i.e. 5-hydroxytryptamine; 5-HT) S1 receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and the 5-HT precursor L-5-hydroxytryptophan (5-HTP) were compared in different models of epilepsy. 5-HTP significantly increased the threshold for electroconvulsions and pentylenetetrazol-induced seizures in mice and ...
W, Löscher, S J, Czuczwar
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The effects of the serotonin (i.e. 5-hydroxytryptamine; 5-HT) S1 receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and the 5-HT precursor L-5-hydroxytryptophan (5-HTP) were compared in different models of epilepsy. 5-HTP significantly increased the threshold for electroconvulsions and pentylenetetrazol-induced seizures in mice and ...
W, Löscher, S J, Czuczwar
openaire +2 more sources