Results 41 to 50 of about 11,570,679 (306)

Identification of causal intervention effects under contagion

Journal of Causal Inference, 2021
Defining and identifying causal intervention effects for transmissible infectious disease outcomes is challenging because a treatment – such as a vaccine – given to one individual may affect the infection outcomes of others. Epidemiologists have proposed
Cai Xiaoxuan, Loh Wen Wei, Crawford Forrest W.   +2 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors

Polish Journal of Food and Nutrition Sciences, 2014
Evening primrose (Oenothera paradoxa Hudziok) seeds are a rich source of not only a valuable oil containing an essential fatty acid - ᵧ-linolenic acid (GLA) - but also polyphenols which can be obtained from the biomass remaining after oil pressing.
Szewczyk Karolina, Lewandowska Urszula, Owczarek Katarzyna, Sosnowska Dorota, Gorlach Sylwia, Koziołkiewicz Maria, Hrabec Zbigniew, Hrabec Elżbieta   +7 more
doaj   +1 more source

Optimal Control of a Dengue-Dengvaxia Model: Comparison Between Vaccination and Vector Control

Computational and Mathematical Biophysics, 2021
Dengue is the most common mosquito-borne viral infection transmitted disease. It is due to the four types of viruses (DENV-1, DENV-2, DENV-3, DENV-4), which transmit through the bite of infected Aedes aegypti and Aedes albopictus female mosquitoes during
Mentuda Cheryl Q.
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Rapid Voltammetric Screening Method for the Assessment of Bioflavonoid Content Using the Disposable Bare Pencil Graphite Electrode

Chemosensors, 2021
Hesperidin (HESP) is a plant bioflavonoid found in various nutritional and medicinal products. Many of its multiple health benefits rely on the compound’s antioxidant ability, which is due to the presence of oxidizable hydroxyl groups in its structure ...
Iulia Gabriela David, Nimet Numan, Mihaela Buleandră, Dana-Elena Popa, Simona Carmen Lițescu, Sorin Riga, Adela Magdalena Ciobanu   +6 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Mathematical analysis of an epidemic model with direct and indirect transmission modes and two delays

Nonautonomous Dynamical Systems, 2023
In this article, we consider an epidemiological model in which we take into account the effects of direct and indirect transmissions. The first mode occurs through direct contact between infectious and susceptible individuals, and the second one will ...
Najm Fatiha, Yafia Radouane, Alaoui My Ahmed Aziz, Tridane Abdessamad, Boukrim Lahcen   +4 more
doaj   +1 more source