Results 61 to 70 of about 1,794,249 (289)

Agrarumweltprogramm mit Ökobilanz im Allgäu zielorientiert gestalten [PDF]

open access: yes, 2000
Mit einer Ökobilanz von 18 Grünlandbetrieben in den drei relevanten Förderprogrammen des Bayerischen Kulturlandschaftsprogramms „Intensiv” - quasi ohne Auflagen, „Extensiviert” - Verbot mineralischer Stickstoffdüngung - und „Ökologischer Landbau” wurden ...
Haas, Guido
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

„Legalizować czy nie?” – analiza związku pomiędzy stosowaniem kanabinoli a częstością występowania i obrazem klinicznym zaburzeń psychotycznych

open access: yesPsychiatria i Psychologia Kliniczna, 2010
Związek pomiędzy zażywaniem kanabinoli a występowaniem zaburzeń psychotycznych jest opisywany od dawna. Udowodniono między innymi, że kanabinole mogą wywoływać przemijające objawy pozytywne, negatywne i poznawcze psychozy u zdrowych osób oraz zaostrzać ...
Marta Gawłowska   +1 more
doaj  

A Utility-Based Rate Allocation of M2M Service in Heterogeneous Wireless Environments

open access: yesInternational Journal of Distributed Sensor Networks, 2013
This paper presents a dynamic adaptive machine-to-machine (M2M) service rate allocation scheme for optimum traffic distribution in heterogeneous wireless environments (HWEs). According to the M2M service characteristics, it proposes the utility function,
Yao Huang   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

CUSTOMER ACCESS INFORMATION TECHNOLOGY (CAIT) DEPLOYMENT EVALUATION [PDF]

open access: yes, 1992
Customer access information technology offers great potential benefits to both the organization and its customers. However, managers lack methods for evaluating these technologies and determining whether conditions exist for success.
Kauffman, Robert J., Lally, Laura
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

A Becker–Döring model with injection and irreversible fragmentation

open access: yesEuropean Journal of Applied Mathematics
We introduce and analyse a variant of the Becker–Döring equations that models the growth of clusters through the gain or loss of monomers. Motivated by enzymatic reactions in biology, this model incorporates irreversible fragmentation and monomers ...
Simon Loin
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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