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Immunology and Allergy Clinics of North America, 2004
Allergic reactions to cephalosporins may occur because of sensitization to cephalosporin determinants shared with penicillin or to unique cephalosporin haptens. The exact nature of the haptenic determinants resulting from the degradation of currently available cephalosporins is incompletely understood.
Arvind, Madaan, James T-C, Li
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Allergic reactions to cephalosporins may occur because of sensitization to cephalosporin determinants shared with penicillin or to unique cephalosporin haptens. The exact nature of the haptenic determinants resulting from the degradation of currently available cephalosporins is incompletely understood.
Arvind, Madaan, James T-C, Li
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Biosynthesis of Cephalosporins
1976Publisher Summary This chapter discusses the biosynthesis of cephalosporins. A variety of cephalosporins and their producers has been found, however it has not been conclusively determined what the secondary metabolites are in a strict sense of the term.
T, Kanzaki, Y, Fujisawa
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Pediatrics In Review, 1998
The cephalosporins are the largest and most diverse family of antimicrobial agents available. Although they rarely are considered drugs of first choice for the therapy of bacterial infections, they are the most commonly prescribed agents for both ambulatory and hospitalized patients.
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The cephalosporins are the largest and most diverse family of antimicrobial agents available. Although they rarely are considered drugs of first choice for the therapy of bacterial infections, they are the most commonly prescribed agents for both ambulatory and hospitalized patients.
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Clinics in Dermatology, 2003
O riginally developed based on research completed in the early 1940s by Professor Giuseppe Brotzu, the cephalosporins have sustained their position as a very significant class of antibiotics worldwide, comprising over one half of the available -lactam antibiotics.
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O riginally developed based on research completed in the early 1940s by Professor Giuseppe Brotzu, the cephalosporins have sustained their position as a very significant class of antibiotics worldwide, comprising over one half of the available -lactam antibiotics.
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Pediatrics In Review, 1994
Introduction The first cephalosporin released for clinical use was cephalothin in 1964. Since that time, more than 20 cephalosporin antibiotics have been introduced. These are the most commonly prescribed antibiotics in the United States and account for the largest share of hospital expenditures. To determine which agent to use for an
T, Darville, T, Yamauchi
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Introduction The first cephalosporin released for clinical use was cephalothin in 1964. Since that time, more than 20 cephalosporin antibiotics have been introduced. These are the most commonly prescribed antibiotics in the United States and account for the largest share of hospital expenditures. To determine which agent to use for an
T, Darville, T, Yamauchi
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Journal of Medicinal Chemistry, 1977
The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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The acidic aqueous degradation of the 7alpha-aminophenylglycinamido-containing cephalosporin cephalexin (1a) has been examined. Two major degradation products have been isolated and characterized: 3-formyl-3,6-dihydro-6-phenyl-2.5(1H,4H)-pyrazinedione (5) and 3-hydroxy-4-methyl-2(5H)-thiophenone (6).
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Continuous deacetylation of cephalosporins
Biotechnology and Bioengineering, 1980AbstractContinuous deacetylation of cephalosporin C, 7âaminocephalosporanic acid, and of 2âmethoxyethyl acetate in packed beds of an immobilized esterase is described by simple empirical equations relating conversion to space velocity and temperature.
Jan, Konecny, M, Sieber
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Classification of Cephalosporins
Drugs, 1987Many cephalosporins are now in clinical use. They have a wide range of activity against different species of bacteria and also differ in their pharmacokinetic and metabolic characteristics. This article outlines a basis for comparison and classification of cephalosporins into 4 groups active mainly against: (1) Gram-positive bacteria; (2) Gram-negative
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