Results 51 to 60 of about 15,174 (156)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ELİF ŞAFAK’IN AŞK ROMANINDA TAASSUP-TASAVVUF ÇATIŞMASI

open access: yesYüzüncü Yıl Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2018
Toplum hâlinde yaşayan insanlar, bu birlikte yaşama ve birlikte varlıklarını sürdürme süreçlerini, toplumun diğer fertlerine saygıya göstermek suretiyle mümkün kılarlar. Saygı, insani ilişkilerin temelini oluşturup daha gelişmiş münasebetlere kapı aralar.
Nurullah Esendemir
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

İvan Bunin’in Arsenyev’in Yaşamı Adlı Romanında Ölüm Teması

open access: yesSelçuk Üniversitesi Edebiyat Fakültesi Dergisi, 2018
İnsanın varlığını sorgulamaya başlamasıyla beraber ortaya çıkan ölüm (yok oluş) kavramı edebiyat da dâhil olmak üzere; din, felsefe, sosyoloji, psikoloji, tıp gibi birçok alanda araştırmacıların ilgi konusu olmuştur.
Kübra Çağlıyan Şakar
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Tobacco Containing Scenes in Some Selected Turkish Movies Released Between 1992 and 2016. [PDF]

open access: yesTurk Thorac J, 2021
Erik HE   +17 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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