Results 71 to 80 of about 15,174 (156)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Boşluğa takıl(may)an bir ses: Abbas Sayar

Bozok Üniversitesi İlahiyat Fakültesi Dergisi, 2016
1923-1999 yılları arasında hayatını sürdüren Abbas Sayar, romanlarıyla adından söz ettirse de asıl sanat hayatına şiirleriyle başlamıştır. Toplam altı şiir kitabı olduğu söylenmektedir.
Kemal Timur
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

CUMHURİYET DÖNEMİNİN ÖNCÜ BİR KADIN FELSEFECİSİ: SEMİHA CEMAL HANIM

Felsefe Dünyası, 2010
Cumhuriyetin ilk kadın felsefecilerinden olan Semiha Cemal Hanım, 1905'te doğmuş ve 1936 vefat etmiştir. Telif edebi-felsefi eserleri ve tercümeleri vardır.
Fulya Bayraktar
doaj  

Halil Baltacı, Tasavvufî Gelenekte Aşk ve Hakîkat: Mecazdan Hakîkate Aşk, Hakîkatten Mecâza Söz, İlâhiyât Yayınları, Ankara, 2022, 186 Sayfa

Burdur İlahiyat Dergisi
Halil Baltacı’nın Tasavvufî Gelenekte Aşk ve Hakîkat: Mecazdan Hakîkate Aşk, Hakîkatten Mecâza Söz adlı eseri, tasavvufî aşkın tarihsel gelişimi, teorik altyapısı ve sembolik ifade biçimlerini inceleyen bir çalışmadır.
İsa Yalçın
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

PLATON’UN SYMPOSION’UNDA AŞK, ÜREME, YARATIM, GÜZELLIK VE ÖLÜMSÜZLÜK İLIŞKISI

Felsefe Dünyası, 2018
Platon diyaloglarında aşkı pek çok boyutuyla tartışma konusu edinir. Bu boyutlar içinde,aşk-üreme, aşk-kozmos, aşk-güzellik, aşk-etik, aşk-siyaset, aşk-yaratım, aşk-ölümsüzlük,aşk-eğitim ilişkisi gibi konular önemli bir yer tutar. Bu konulardan kimileri,
Hasan Aydın
doaj  

Wattpad as a resource for literary studies. Quantitative and qualitative examples of the importance of digital social reading and readers' comments in the margins. [PDF]

PLoS One, 2020
Pianzola F, Rebora S, Lauer G.
europepmc   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source