Results 81 to 90 of about 1,115,074 (239)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

How to Ask Good Questions? Try to Leverage Paraphrases

Annual Meeting of the Association for Computational Linguistics, 2020
Given a sentence and its relevant answer, how to ask good questions is a challenging task, which has many real applications. Inspired by human’s paraphrasing capability to ask questions of the same meaning but with diverse expressions, we propose to ...
Xin Jia, Wenjie Zhou, Xu Sun, Yunfang Wu
semanticscholar   +1 more source

Freud’un Görüşleri Ekseninde “Cemile” Hikâyesinde Aşk

, 2021
Aşk, insanlık tarihi boyunca çeşitli görüşler, inançlar ve kabuller bağlamında farklı bakış açıları kazanmış ve kendisine gerek birbirlerine yakın gerekse tamamen uzak pencereler edinerek anlam dağarcığını genişletmiştir.
Yılmaz, Fatih, Fatih Yılmaz, Fatih YILMAZ   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Köroğlu’nun Çoruh Kolu Hikâyesinde Kahramanın Yolculuğu: Campbell Modeli Bağlamında Karşılaştırmalı Bir İnceleme

Dil ve Edebiyat Araştırmaları Dergisi
Bu çalışma, Türk halk anlatılarının önemli örneklerinden biri olan “Köroğlu’nun Çoruh Kolu” hikâyesini Joseph Campbell’in Kahramanın Yolculuğu modeli bağlamında halk anlatılarının evrensel anlatı yapılarıyla nasıl örtüştüğünü analiz etmeyi amaçlamaktadır.
Sedat Bahadır
doaj   +1 more source

Şakarim’in Şiirlerinde Uluhiyet Meselesi (Tanrı’nın Varlığının Delilleri)

İdrak Dini Araştırmalar Dergisi, 2022
Tanrı’yı tanımak, onun sıfat ve fiillerini incelemekle mümkün olabilir. Tanrı’yı tanımak aynı zamanda insanın kendisini tanımak demektir. Çünkü insanın benlik bilgisi Tanrı’nın bilgisinden kaynaklanmaktadır.
Nurlybek Zhanykulov
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Ask not what economics can do for sports - Ask what sports can do for economics

, 2020
In this article we list the advantages of using sports data for economic research. We also provide a rich overview of economic literature that used sports data to test different fundamental economic theories as well as articles that presented divergences
M. Bar-eli, Alex Krumer, Elia Morgulev
semanticscholar   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source