Results 71 to 80 of about 2,899,458 (298)
Механика машин, механизмов и материалов, 2010 In this paper, we analyze the development of research and test methods as well as existing international norms and standards used as a framework for further improvement of the electronic stability control system of motor vehicles.
S.V. Lyakhov
doaj
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Drug Design, Development and Therapy, 2012 Olivier Lambert, Dirk BandillaActelion Pharmaceuticals Ltd, Allschwil, SwitzerlandBackground: The aim of this study was to evaluate the stability and microbiological properties of a formulation of epoprostenol sodium with L-arginine and sucrose ...
Lambert O, Bandilla D
doaj
Impact of collision models on the physical properties and the stability of lattice Boltzmann methods [PDF]
, 2020 C. Coreixas +3 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Stability of membranous nanostructures: a possible key mechanism in cancer progression
International Journal of Nanomedicine, 2012 Veronika Kralj-IglicBiomedical Research Group, Faculty of Health Sciences, University of Ljubljana, Zdravstvena 5, Ljubljana, SloveniaAbstract: Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes.
Kralj-Iglic V
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Drug Design, Development and Therapy, 2012 Olivier Lambert1, Dirk Bandilla1, Rupa Iyer2, Leonore Witchey-Lakshmanan3, Nagesh Palepu41Actelion Pharmaceuticals Ltd, Allschwil, Switzerland; 2TPM Laboratories Inc, Cherry Hill, NJ, USA; 3Pharma CMC/IP, Piscataway, NJ, USA; 4SciDose LLC, Amherst, MA ...
Lambert O +4 more
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source