Results 11 to 20 of about 995,911 (334)

Annexin‐A1: The culprit or the solution? [PDF]

open access: yesImmunology, 2022
Annexin‐A1 has a well‐defined anti‐inflammatory role in the innate immune system, but its function in adaptive immunity remains controversial. This glucocorticoid‐induced protein has been implicated in a range of inflammatory conditions and cancers, as ...
Lauren Kelly   +7 more
semanticscholar   +4 more sources

The Multifaceted Role of Annexin A1 in Viral Infections

open access: yesCells, 2023
Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the ...
Filipe Resende   +4 more
semanticscholar   +1 more source

Molecular basis of V-ATPase inhibition by bafilomycin A1

open access: yesNature Communications, 2021
Pharmacological inhibition of vacuolar-type H+-ATPase (V-ATPase) by its specific inhibitor can abrogate tumor metastasis, prevent autophagy, and reduce cellular signaling responses.
Rong Wang   +5 more
semanticscholar   +1 more source

Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway

open access: yesJournal of Neuroinflammation, 2022
Background Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT 2B receptor (5-HT 2B R), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT 2B R is not fully ...
Yin-quan Fang   +13 more
semanticscholar   +1 more source

Synthesis of (.+‐.)‐Phloeodictine A1. [PDF]

open access: yesChemInform, 2003
The antitumor antibiotic phloeodictine A1 (2) has been synthesized by a convergent seven-step route in 8% overall yield. The key step was the Eguchi aza-Wittig reaction of 6 to give 13 followed by a retro Diels-Alder reaction to liberate 5. Addition of 11-dodecenylmagnesium bromide to 5 to give 4b, alkylation with 18b, and deprotection completed the ...
Bobbianna J, Neubert, Barry B, Snider
openaire   +2 more sources

Integrated and Organic Systems of Sustainable Agriculture in Poland Over the Period 2010–2020

open access: yesStudia Ekonomiczne i Regionalne, 2023
The purpose of the publication is to present two sustainable farming systems in Poland - the system of integrated production and organic farming in 2010 and 2020.
Kokoszka Jakub
doaj   +1 more source

Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke

open access: yesAging and Disease, 2022
Astrocytes play an essential role in the modulation of blood-brain barrier function. Neurological diseases induce the transformation of astrocytes into a neurotoxic A1 phenotype, exacerbating brain injury.
Qi Zhang   +11 more
semanticscholar   +1 more source

Impact of Public Investments on the Local Development of the Sarnaki Commune in the Years 2014-2020

open access: yesStudia Ekonomiczne i Regionalne, 2021
Subject and purpose of work: The aim of the work was to show the impact of the implemented public investments and development projects on the local development and the changes that occurred, as well as on the living conditions of the inhabitants of the ...
Zaręba Piotr, Chwedorczuk Monika
doaj   +1 more source

Astrocytic A1/A2 paradigm participates in glycogen mobilization mediated neuroprotection on reperfusion injury after ischemic stroke

open access: yesJournal of Neuroinflammation, 2021
Background Astrocytic glycogen works as an essential energy reserve for surrounding neurons and is reported to accumulate excessively during cerebral ischemia/reperfusion (I/R) injury.
Haiyun Guo   +11 more
semanticscholar   +1 more source

Effect of nanoclay (Kaolinite) on mechanical properties of epoxy-fiber composite

open access: yesJournal of Kufa-Physics, 2020
An experimental investigation using drag-out tensile test to calculate the interfacial shear strength for different embedded lengths of Kevlar and carbon fibers reinforced epoxy matrix with nanoclay (kaolinite) for different ratio weight, the ...
Hisham M Hasan, Ahmed R Majeed
doaj   +1 more source

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