Results 61 to 70 of about 747,724 (298)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Blockchain-enabled food traceability system and consumers’ organic food consumption: A moderated mediation model of blockchain knowledge and trust in the organic food chain

Sustainable Futures
Although the role of blockchain technology application in the organic food supply chain has been scholarly acknowledged, our understanding of how blockchain-enabled food traceability impacts consumer trust and purchase decisions is still limited ...
Cong Doanh Duong, Thanh Tung Dao, Trong Nghia Vu, Thi Viet Nga Ngo, Minh Hoa Nguyen   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Supplement figures A1--A28 and Tables A1--A6 [PDF]

, 2018
Online supplementary figures A1 -- A28 and tables A1--A6.
Jonas Eberle (569682), Erika Bazzato (5897966), Davide Cillo (5897972), Mariastella Colomba (5755001), Michele Rossini (5897969), Marco Uliana (5897975), Dirk Ahrens (569684), Silvia Fabrizi (3292884), Rachel Warnock (3299676), Ignazio Sparacio (5897978), Guido Sabatinelli (5897981), Giuseppe Carpaneto (3097860)   +11 more
core   +1 more source

Métastases septique neuro-méningée suite à une otite à pneumocoque

The Pan African Medical Journal, 2015
Nous rapportons l'observation médicale d'un patient de 39 ans admis dans notre formation pour méningite à Pneumocoque à point de départ ORL (Otite purulente) non traité 10 jours auparavant. L'évolution était favorable sous Ceftriaxone 50mg/kg/12h. La TDM
Coulibaly Mahamadoun, Mohamed Khatouf
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Bioenergetic properties of the Thermoalkaliphilic Bacillus sp. Strain TA2.A1 [PDF]

, 2003
The thermoalkaliphilic Bacillus sp. strain TA2.A1 was able to grow in pH-controlled batch culture containing a nonfermentable growth substrate from pH 7.5 to 10.0 with no significant change in its specific growth rate, demonstrating that this bacterium ...
Olsson, Karen, Cook, Gregory M., Dimroth, Peter, Keis, Stefanie, Morgan, Hugh W., https://orcid.org/   +5 more
core   +1 more source

La mucormycose rhino-orbito-cérébrale

The Pan African Medical Journal, 2012
La mucormycose est une infection fongique rarissime et souvent fatale, elle est due à la prolifération dans différents tissus de champignon opportuniste de la famille des mucorales.
Ali Derkaoui, Mohammed Khatouf
doaj   +1 more source

Candida tropicalis defibrillator endocarditis: A case report and review of current literature

Medical Mycology Case Reports, 2019
We provide a review of current literature and report on a case of electronic device infective endocarditis with C. tropicalis. A 64-year-old man presented for revision of his implantable cardioverter defibrillator.
Bastian Klemens Bauer, Arik Bernhard Schulze, Andreas Löher, Florian Reinke, Lars Eckardt   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source