Results 81 to 90 of about 1,719,750 (297)

Chemical and pharmacological profile of selective adenosine receptor agonists

, 1996
There is evidence that the purine nucleoside adenosine specifically modulates neurotransmission through the interaction with four cell surface receptors recently classified as A1, A2a, A2b, and A3.
Di Francesco E, S. Vittori, E. Camaioni, R. Volpini, VITTORI, Sauro, CRISTALLI, Gloria, Camaioni E, VOLPINI, Rosaria, E. Di Francesco, G. Cristalli   +9 more
core   +2 more sources

5'-Chloro-5'-deoxy-(±)-ENBA, a Potent and Selective Adenosine A1 Receptor Agonist, Alleviates Neuropathic Pain in Mice Through Functional Glial and Microglial Changes without Affecting Motor or Cardiovascular Functions

Molecules, 2012
This study was undertaken in order to investigate the effect of chronic treatment with 5′-chloro-5′-deoxy-(±)-ENBA, a potent and highly selective agonist of human adenosine A1 receptor, on thermal hyperalgesia and mechanical ...
Livio Luongo, Riccardo Petrelli, Luisa Gatta, Catia Giordano, Francesca Guida, Patrizia Vita, Palmarisa Franchetti, Mario Grifantini, Vito de Novellis, Loredana Cappellacci, Sabatino Maione   +10 more
doaj   +1 more source

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Protective effect of Adenosine A1 receptor and ascorbic acid on hippocampal neuronal density and memory disorder in ischemia reperfusion induced Rats

مجله دانشگاه علوم پزشکی گرگان, 2012
Background and Objective: Brain ischemia is one of the most important factor of morbidity and mortality and leaving many people with mental and physical disabilities.
Zamani M (MSc), Rasooli H (PhD), Mehdizadeh M (PhD), Nobakht M (PhD), Zamani F (BSc), Soleimani M (PhD)   +5 more
doaj  

Possible involvement of A1 receptors in the inhibition of gonadotropin secretion induced by adenosine in rat hemipituitaries in vitro

Brazilian Journal of Medical and Biological Research, 1999
We investigated the participation of A1 or A2 receptors in the gonadotrope and their role in the regulation of LH and FSH secretion in adult rat hemipituitary preparations, using adenosine analogues.
D.L.W. Picanço-Diniz, M.M. Valença, A.L.V. Favaretto, S.M. McCann, J. Antunes-Rodrigues   +4 more
doaj   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Cloning and functional characterization of a human A1 adenosine receptor.

, 1992
A human brain hippocampus cDNA library was screened by hybridization with a dog A1 adenosine receptor cDNA probe. Sequencing of the resulting clones identified a 978 residue open reading frame encoding a 326 amino acid polypeptide showing 95.7 ...
Libert, Frédérick, Czernilofsky, A, Dumont, Jacques, Lefort, Anne, Ensinger, H A, Mendla, K D, Vassart, Gilbert, Van Sande, Jacqueline   +7 more
core   +1 more source

Investigating the Effect of Inclination Angle and the Influence of Scan Parameters on the Appearance and Thermal and Mechanical Properties of Filigree Tension Rods of LPBF‐Manufactured NiTi Shape‐Memory Alloys

Advanced Engineering Materials, EarlyView.
This article investigates the dependence of the properties on the manufacturing orientation in the form of the inclination angle to the build plate of LPBF‐fabricated NiTi rods with a diameter of 150–220 µm. Metallographic, chemical, thermal, and mechanical characterization show behavior under identical manufacturing conditions that ranges from ...
Sandra Herzig, Michael Werner, Christian Rotsch   +2 more
wiley   +1 more source

Affinity and selectivity of tecadenoson, 2-chloro-tecadenoson and 2’-C-methyl analogues at bovine and pig A1 adenosine receptor

, 2005
Adenosine A1 receptor agonists have a great interest as neuroprotective agents for the treatment of glutamate-related neurodegenerative disorders and as antilipolytic agents.
PASQUALINI M., COSTA B., FRANCHETTI, Palmarisa, KLOTZ K., CAPPELLACCI, Loredana, VITA, PATRIZIA, PETRELLI, Riccardo, MARTINI C., SPINETTI F., LAVECCHIA A., GRIFANTINI, Mario   +10 more
core   +1 more source