Results 141 to 150 of about 3,774 (171)

Diagnose und Heimselbsttherapie eines Patienten mit schwerem A1AT-Mangel mit homozygotem Genotyp MNichinan

Pneumologie, 2020
A. Kaa, M. Wencker
semanticscholar   +2 more sources

Novel Biological Functions of A1AT

, 2017
S. Janciauskiene
semanticscholar   +2 more sources

Diagnose und Verlauf eines schweren Alpha1 Antitrypsin (A1AT)-Mangels PiZM(Heerlen)

Pneumologie, 2019
T. Wustmann, M. Wencker
semanticscholar   +2 more sources

Alpha1-antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency

Human Pathology, 1972
Abstract An inherited deficiency of alpha 1 -antitrypsin (A 1 AT) in human serum predisposes to the development of pulmonary emphysema. A 1 AT is synthesized primarily by the liver, but no specific liver abnormality has been described in deficient subjects with lung disease. Fourteen of 17 livers from emphysematous patients with a Pi z variant of A 1
H W, Gordon, J, Dixon, J C, Rogers, C, Mittman, J, Lieberman   +4 more
openaire   +2 more sources

A1AT In Human Neutrophil Granulocytes.

Blood, 2010
Abstract Abstract 3784 Alpha-1-antitrypsin (A1AT) is an important inhibitor of the neutrophil serine proteases elastase, cathepsin G, and proteinase 3. A1AT is produced mainly by the liver and secreted to plasma. A1AT deficiency caused by the PiZZ mutation in the A1AT gene leads to accumulation of mutated A1AT in the liver
Stine Novrup Clemmensen, Lars C. Jacobsen, Sara Roervig, Bent Adel Hansen, Martin Iversen, Jack B Cowland, Bo van Deurs, Bjarke Askaa, Niels Borregaard   +8 more
openaire   +1 more source

EFFECT OF INHALED CHROMIUM ON PULMONARY A1AT

Inhalation Toxicology, 2002
A major health hazard to coal miners is development of emphysema following long-term exposure to coal dust. One mechanism underlying development of emphysema is the oxidation of critical methionine (Met) residues in antiproteolytic factor, alpha1-antitrypsin (A1AT) resulting in a protease-antiprotease imbalance in the lung.
Mitchell D. Cohen, Maureen Sisco, Kathy Baker, Lung-Chi Chen, Richard B. Schlesinger   +4 more
openaire   +2 more sources

A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease

Case Medical Research, 2019

semanticscholar   +2 more sources

a1-antitrypsin (A1AT) deficiency presenting with IgA nephropathy and nephrotic syndrome: is renal involvement caused by A1AT deposition?

Clinical Nephrology, 2008
The role of severe a1-antitrypsin (A1AT) deficiency in the predisposition of early-onset pulmonary emphysema and juvenile hepatic cirrhosis is well-established. Associated glomerulonephritis is unusual although it is well-recognized in children and young adults with the severe phenotype. We report the first adult case of A1AT deficiency presenting with
S M S, Ting, T, Toth, F, Caskey
openaire   +2 more sources

A Case of Progressive Panlobular Emphysema in an Adult Nonsmoker With Normal A1AT Levels

Chest, 2015
M. McMahon, N. Bhatt
semanticscholar   +2 more sources

Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent

NeuroToxicology, 2012
Persons with single copies of common alpha-1-antitrypsin polymorphisms such as S and Z are often considered "silent carriers". Published evidence however supports a complex behavioral phenotype or trait - intense creative energy ("ICE")-associated with A1AT polymorphisms. We now confirm that phenotype and present an association of fibromyalgia syndrome
Donald E, Schmechel, Christopher L, Edwards   +1 more
openaire   +2 more sources