Results 161 to 170 of about 3,462 (201)

Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy. [PDF]

Adv Sci (Weinh)
Yang K, Chu X, Wang X, Zhang W, Lu J, Xu C, Hu S, Pan G, Yang CT, Zhang X, Li S, Guo Z, Liu H, Ge G.   +13 more
europepmc   +1 more source

SputOMICs identifies common and distinct markers in cystic fibrosis and chronic obstructive pulmonary disease. [PDF]

Sci Rep
Frey DL, Helm B, Guerra M, Hagner M, Lu J, Dittrich AS, Wege S, Eberhardt R, Herth FJF, Sommerburg O, Schultz C, Dalpke AH, Klingmüller U, Mall MA, Boutin S.   +14 more
europepmc   +1 more source

Significant Changes in Low-Abundance Protein Content Detected by Proteomic Analysis of Urine from Patients with Renal Stones After Extracorporeal Shock Wave Lithotripsy. [PDF]

Biology (Basel)
Carestia E, Di Giuseppe F, Kazemi M, Ramahi M, Priyadarshi U, Giuliani P, De Francesco P, Schips L, Di Ilio C, Ciccarelli R, Di Iorio P, Angelucci S.   +11 more
europepmc   +1 more source

Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection [PDF]

BMC Urology, 2013
Abstract Background In this study, we further investigated the association of two biomarkers, CCL18 and A1AT, with bladder cancer (BCa) and evaluated the influence of potentially confounding factors in an experimental model.
Makito Miyake, Shanti Ross, Myron Chang   +2 more
exaly   +5 more sources

Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2015
In addition to exerting a potent anti-elastase function, α-1 antitrypsin (A1AT) maintains the structural integrity of the lung by inhibiting endothelial inflammation and apoptosis. A main serpin secreted in circulation by hepatocytes, A1AT requires uptake by the endothelium to achieve vasculoprotective effects.
Daniela N Petrusca, Matthew J Justice, Christophe Poirier   +2 more
exaly   +5 more sources

Diagnosis and Management of Patients With α1-Antitrypsin (A1AT) Deficiency [PDF]

Clinical Gastroenterology and Hepatology, 2012
Alpha(1)-antitrypsin (A1AT) deficiency is an autosomal codominant disease that can cause chronic liver disease, cirrhosis, and hepatocellular carcinoma in children and adults and increases risk for emphysema in adults. The development of symptomatic disease varies; some patients have life-threatening symptoms in childhood, whereas others remain ...
David R Nelson, Jeffrey H Teckman
exaly   +3 more sources

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Alpha1-antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency

Human Pathology, 1972
Abstract An inherited deficiency of alpha 1 -antitrypsin (A 1 AT) in human serum predisposes to the development of pulmonary emphysema. A 1 AT is synthesized primarily by the liver, but no specific liver abnormality has been described in deficient subjects with lung disease. Fourteen of 17 livers from emphysematous patients with a Pi z variant of A 1
Charles Mittman, Jack Lieberman
exaly   +3 more sources

Purified A1AT holds promise as therapy for acute liver failure [PDF]

Nature Reviews Gastroenterology and Hepatology, 2014
Katrina Ray
exaly   +3 more sources

EFFECT OF INHALED CHROMIUM ON PULMONARY A1AT

Inhalation Toxicology, 2002
A major health hazard to coal miners is development of emphysema following long-term exposure to coal dust. One mechanism underlying development of emphysema is the oxidation of critical methionine (Met) residues in antiproteolytic factor, alpha1-antitrypsin (A1AT) resulting in a protease-antiprotease imbalance in the lung.
Mitchell D Cohen, Lung Chi Chen, Richard B Schlesinger   +2 more
exaly   +3 more sources

A1AT In Human Neutrophil Granulocytes.

Blood, 2010
Abstract Abstract 3784 Alpha-1-antitrypsin (A1AT) is an important inhibitor of the neutrophil serine proteases elastase, cathepsin G, and proteinase 3. A1AT is produced mainly by the liver and secreted to plasma. A1AT deficiency caused by the PiZZ mutation in the A1AT gene leads to accumulation of mutated A1AT in the liver
Stine Novrup Clemmensen, Lars C. Jacobsen, Sara Roervig, Bent Adel Hansen, Martin Iversen, Jack B Cowland, Bo van Deurs, Bjarke Askaa, Niels Borregaard   +8 more
openaire   +1 more source