Results 171 to 180 of about 5,912 (202)

Is the diagnostic rate for the common subtypes of A1AT deficiency consistent across two Canadian Provinces?

Clinical Biochemistry, 2021
The diagnosis of alpha-1-antitrypsin (A1AT) deficiency has been hindered by obscurity concerning the testing process and treatment implications. In this study, we aimed to identify regional differences in the diagnostic rates for A1AT deficiency in the western Canadian provinces of British Columbia (BC) and Alberta (AB).The number of A1AT deficiency ...
Tania Tahooni, Terence A Agbor, Hui-Min Yang   +2 more
exaly   +3 more sources

EFFECT OF INHALED CHROMIUM ON PULMONARY A1AT

Inhalation Toxicology, 2002
A major health hazard to coal miners is development of emphysema following long-term exposure to coal dust. One mechanism underlying development of emphysema is the oxidation of critical methionine (Met) residues in antiproteolytic factor, alpha1-antitrypsin (A1AT) resulting in a protease-antiprotease imbalance in the lung.
Mitchell D. Cohen, Maureen Sisco, Kathy Baker, Lung-Chi Chen, Richard B. Schlesinger   +4 more
exaly   +3 more sources

Scavenger receptor class B, type I-mediated uptake of A1AT by pulmonary endothelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2015
In addition to exerting a potent anti-elastase function, α-1 antitrypsin (A1AT) maintains the structural integrity of the lung by inhibiting endothelial inflammation and apoptosis. A main serpin secreted in circulation by hepatocytes, A1AT requires uptake by the endothelium to achieve vasculoprotective effects.
Angelia D Lockett, Daniela N Petrusca, Karina A Serban   +2 more
exaly   +4 more sources

Identification of citrullinated α1-antitrypsin (A1AT) in saliva in a mouse model of rheumatoid arthritis

Journal of Oral Biosciences
Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive joint destruction. Early diagnosis and treatment, before joint deformation or destruction occurs, are crucial. Identifying novel biomarkers for RA in saliva could potentially enable early detection of the disease, prior to its onset.We conducted a comprehensive proteomic ...
Wakako Sakaguchi, Juri Saruta, Keiichi Tsukinoki   +2 more
exaly   +3 more sources

Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent

NeuroToxicology, 2012
Persons with single copies of common alpha-1-antitrypsin polymorphisms such as S and Z are often considered "silent carriers". Published evidence however supports a complex behavioral phenotype or trait - intense creative energy ("ICE")-associated with A1AT polymorphisms. We now confirm that phenotype and present an association of fibromyalgia syndrome
Donald E, Schmechel, Christopher L, Edwards   +1 more
openaire   +2 more sources

Development of an Inhalation LNP Therapy for the Treatment of Lung Disease in A1AT-Deficiency Disorder, Utilizing an A1AT KO Ferret Model

American Journal of Respiratory and Critical Care Medicine
Abstract Rationale: Alpha-1 Antitrypsin (A1AT) deficiency is a rare genetic disorder caused by mutations in the SERPINA1 gene, resulting in insufficient levels of functional A1AT protein. This deficiency results in unregulated neutrophil elastase activity in the lung, damaging pulmonary histoarchitecture and causing pathological ...
J. Chen, P. Sahni, S. Fakhari, M. Shilotri, T.-L. Hsu, C. Ceballos-Diaz, B. Tejera-Hernandez, H. Meng, W. Hartono, S. Katikaneni, S. Mohapatra, J. Cefalu, R. Tran, S. Sherman, D. Bartels, M.M. Kim, D.J. Lockhart, J. Couch, M.S. Weinberg   +18 more
openaire   +1 more source

Alpha-1-antitrypsin (A1AT) serum concentration in newborns is susceptible to diurnal variations

European Respiratory Journal, 2013
Laboratory evaluation of A1AT deficiency involves measurement of circulating A1AT protein (quantitation) and characterization of A1AT genetic polymorphisms. In contrast to adult and pediatric populations, there are no reliably documented A1AT serum reference ranges for newborns available.
Joanna Chorostowska-Wynimko, Radoslaw Struniawski, Beata Poplawska, Maria Borszewska-Kornacka   +3 more
openaire   +1 more source

Evidence for alpha-1-antitrypsin (A1AT) polymerization in preeclampsia: A novel mechanism for endothelial cell injury

American Journal of Obstetrics and Gynecology, 2006
PREECLAMPSIA: A NOVEL MECHANISM FOR ENDOTHELIAL CELL INJURY IRINA BUHIMSCHI, GUOMAO ZHAO, GEORGE SAADE, CATALIN S. BUHIMSCHI, Yale University, Obstetrics/Gynecology, New Haven, Connecticut, Yale University, Ob./Gyn.R p=0.009], despite a significant increase its urinary excretion (O500 fold in sPE, p!0.001).
Irina Buhimschi, Guomao Zhao, George Saade, Catalin S. Buhimschi   +3 more
openaire   +1 more source

The incidence of alpha-1-antitrypsin (A1AT) deficiency alleles in patients with pulmonary Langerhans cell histiocytosis

European Respiratory Journal, 2013
Introduction: Inherited alpha-1 antitrypsin deficiency (A1ATD) is one of the three most common genetic disorders in Caucasians. It considerably increases the risk of progressive obstructive lung diseases, mostly chronic obstructive pulmonary disease.
Elzbieta Radzikowska, Radoslaw Skoronski, Joanna Chorostowska-Wynimko, Elzbieta Wiatr, Beata Poplawska, Kazimierz Roszkowski-Sliz, Agnieszka Jarzemska   +6 more
openaire   +1 more source

Influence of pregnancy on diurnal and seasonal changes in glucose level and activity of FDPA, A1AT and AspAT in mares

Comparative Biochemistry and Physiology A, Comparative Physiology, 1991
Abstract 1. 1. The diurnal changes in the glucose level and in activity of FDPA, A1AT and AspAT in four pregnant standard-bred mares were studied. 2. 2. As a control four barren mares, were kept and examined in the same conditions. 3. 3. Blood samples were taken every 4hr for one day, each month, throughout pregnancy, or one year.
Anna FlisiŃska-Bojanowska, Małgorzata Komosa, Janusz Gill   +2 more
exaly   +2 more sources