Results 71 to 80 of about 1,152,301 (120)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Genetic analysis of the Montbeliard breed for the suitability of A2 milk use in food technologies

Біологічні студії
Background. Cow milk has long been a source of protein and certain micronutrients, such as calcium. A2 milk is gaining popularity among consumers who are constantly looking for healthy foods.
Olha Yakubenko, Nataliia Mokhnachova, Svitlana Danylenko, Ostap Zhukorskyi, Hanna Kozlovska, Oleksandr Verheles   +5 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Genetic Diversity of the Beta‐Casein Gene in Brown Swiss and Creole Cattle From the Peruvian Highlands

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT Cattle's milk and derivatives are essential for human nutrition. However, up to 90% of people experience gastrointestinal discomfort after consumption. Milk digestibility depends on its protein composition. Casein, about 80% of milk proteins, includes beta‐casein (CSN2) with two variants: A1 and A2. The A1 variant is linked to gastrointestinal
Lucy R. Remigio Lorenzo, Cristina Rivera Romero, Joao De Souza Pacheco, Wilder Bueno Cabrera, Eduardo L. Fuentes Navarro, Rudolf Pichler, Kathiravan Periasamy, Gustavo A. Gutiérrez‐Reynoso   +7 more
wiley   +1 more source

Effects of A1 Milk, A2 Milk and the Opioid-like Peptide β-Casomorphin-7 on the Proliferation of Human Peripheral Blood Mononuclear Cells

Biomolecules
Special attention is given to cow’s milk and its variants, with ongoing discussions about health-related impacts primarily focusing on the A1 variant in contrast to the A2 variant.
Felix Gard, Lili M. Flad, Tanja Weißer, Hermann Ammer, Cornelia A. Deeg   +4 more
doaj   +1 more source

Nano‐Engineered Yogurt as a Functional Delivery Platform: From Encapsulation Technologies to Personalized Nutrition

eFood, Volume 7, Issue 3, June 2026.
Graphical abstract showing nanoencapsulation‐based yogurt fortification, highlighting nanocarrier incorporation, improved storage stability, enhanced bioaccessibility, targeted gastrointestinal release, nutrient absorption, and gut microbiota modulation.
Farhang Hameed Awlqadr, Mohammed N. Saeed, Ammar B. Altemimi, Ahmad F. Hama Sdiq, Othman Abdulrahman Mohammed, Sonia Morya, Syamand Ahmed Qadir, Tablo H. Salih, Khaled Arab   +8 more
wiley   +1 more source

Health-related outcomes of genetic polymorphism of bovine β-casein variants:A systematic review of randomised controlled trials

, 2021
Background: A number of randomised in vivo trials have to date investigated the health impacts of the genetic variants A1 and A2 of bovine β-casein.
Vasiljevic, Todor, McCarthy, Noel A, McParland, S, Daniloski, Davor, Cunha, NMD, D'Cunha, Nathan M; id_orcid, O'Callaghan, Tom F, McCarthy, Noel A., O'Callaghan, Tom F., McParland, Sinéad   +9 more
core   +1 more source

Comparative Analysis of Rapid and Less Invasive Methods for A2A2 Dairy Cattle Genotyping and A2 Milk Purity Detection

Dairy
In this study, two methods for assessing the purity of A2 fermented milk and β-casein genotypes in dairy cows were examined. The need for rapid and precise methods for herd screening and A2 milk quality control justified this study. Accordingly, an ELISA
Leandra Oliveira Xavier Albiero, Rafaela Ansiliero, Aniela Pinto Kempka   +2 more
doaj   +1 more source

The Impact of A1- and A2 β-Casein on Health Outcomes: A Comprehensive Review of Evidence from Human Studies

Applied Sciences
The digestion of A1 β-casein present in conventional milk releases β-casomorphin-7 (βCM-7), a bioactive peptide with potential implications for gastrointestinal and neurological health.
Nerea González-Rodríguez, Natalia Vázquez-Liz, Ana Rodríguez-Sampedro, Patricia Regal, Cristina Fente, Alexandre Lamas   +5 more
doaj   +1 more source

Proline‐Selective Electrochemiluminescence Detecting a Single Amino Acid Variation Between A1 and A2 β‐Casein Containing Milks

Advanced Science
The proline amino acid and prolyl residues of peptides/proteins confer unique biological and biochemical properties that motivates the development of proline‐selective analysis.
Eunkyoung Kim, Chen‐Yu Chen, Monica J. Chu, Mya F. Hamstra, William E. Bentley, Gregory F. Payne   +5 more
doaj   +1 more source