Results 71 to 80 of about 308,524 (151)

The shared genetic architecture of the TDP‐43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract INTRODUCTION TAR DNA‐binding protein 43 (TDP‐43) proteinopathies encompass a spectrum of conditions including frontotemporal lobar degeneration with TDP‐43 inclusions (FTLD‐TDP), limbic‐predominant age‐related TDP‐43 encephalopathy (LATE‐NC), and hippocampal sclerosis (HS).
Maulikkumar Patel, Pawan Kumar, Daniel Western, Matthew Johnson, Menghan Liu, John Budde, Carlos Cruchaga, Cyril Pottier   +7 more
wiley   +1 more source

Investigating the Role of Annexin A2 in Astrocyte-Mediated Clearance of Tau Aggregates

reservedFor many years, astrocytes were primarily thought to function as supportive and structural elements in the brain. However, recent studies have revealed that they play much more complex and significant roles in the central nervous system (CNS ...
ZANON, ILARIA
core  

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury by regulating the Cx43

Purpose: To explore the mechanism by which Remazolam affects the phenotype and function of astrocytes to improve traumatic brain injury (TBI). Methods: The oxygen -glucose deprivation/recovery (OGD/R) cell model was constructed to simulate the ...
Wenting Shen, Yang Tan, Congli Mao, Ying Zhao, Jing Xia   +4 more
core   +1 more source

Pan‐Adrenergic Inhibition Alleviates Post‐Hemorrhagic Hydrocephalus by Attenuating Neutrophil Extracellular Traps‐Mediated Glymphatic Dysfunction

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Intraventricular hemorrhage induces an adrenergic response that activates PI3K/AKT/mTOR signaling and promotes neutrophil extracellular trap (NET) formation, impairing glymphatic clearance and aggravating post‐hemorrhagic hydrocephalus (PHH). Pan‐adrenergic inhibition after hemorrhage reduced PI3K/AKT/mTOR activation and NET formation, preserved AQP4 ...
Yijian Yang, Yanjie Zhou, Qian Ouyang, Hanati Nuerlanbieke, Yexin Yuan, Junqiang Wang, Kaiyue Wang, Peng Long, Yifeng Chen, Zhikun Liu, Jun Huang, Zhiping Zhang, Zhangjie Su, Xia Wang, Gelei Xiao   +14 more
wiley   +1 more source

Brain‐Derived Neurotrophic Factor (BDNF), Estrogen Receptors, and Mossy Cells

Hippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Dentate gyrus (DG) function depends on the neurotrophin brain‐derived neurotrophic factor (BDNF) which shows robust synthesis in the principal cells, the granule cells (GCs). However, BDNF protein is present in the inner molecular layer (IML), where most afferents to GCs are from hilar mossy cells (MCs). Therefore, we asked whether MCs express
Chiara Criscuolo, Monarchsinh Rathod, Fang Jie, Helen E. Scharfman   +3 more
wiley   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Transmission electron microscopy of retinal macroglia.

, 2016
A1,A2: G0 control; B1,B2: G1 hypercholesterolemic; C1,C2: G2 statins. Astrocytes (A1-C1). Müller cells (A2-C2). In G1 (B1,B2), some astrocytes and Müller cells were necrotic (*) and some others were reactive with abundant organelles, glial filaments, and
Judith Fernández-Navarro (2656903), Alberto Triviño (499408), Beatriz I. Gallego (499404), Rosa de Hoz (419547), Pilar Aldea (2656906), Ana I Ramírez (2656912), Teresa Tejerina (366052), Juan J Salazar (2656909), José M. Ramírez (419551), Blanca Rojas (419549)   +9 more
core   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses »

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Samanta Plavina, Daniela Malakovska, Jolanta Kalnina, Ilva Trapina, Elina Leonova, Mohammed Habib, Susanne Schifmann, Jegors Paramonovs, Nikolajs Sjakste, Yegor Vassetzky, Emmanuel Drouet, Natalia Paramonova   +11 more
wiley   +1 more source

GABAergic Network Dysregulation in Alcohol Use Disorder: Receptor–Transporter Interactions Driving the Transition From Goal‐Directed to Compulsive Behaviour

Addiction Biology, Volume 31, Issue 11, November 2026.
Astrocytic GAT3 regulates ambient GABA levels in the globus pallidus externus (GPe). Reduced GAT3 function enhances extrasynaptic GABAergic signalling and disrupts subthalamic nucleus (STN) regulation and cortical signal fidelity.ABSTRACTAlcohol use disorder (AUD) is characterized by a shift from controlled, goal‐directed drinking to compulsive ...
Hannah Aranda, Nathan Jones, Humza Haroon, Doo‐Sup Choi   +3 more
wiley   +1 more source