Results 61 to 70 of about 308,524 (151)
Occurrence of the A2 matyng type and Self isolates of Phytophthora infestans in Italy [PDF]
, 1997 Among one hundred and sixty-four isolates of Phytophthora infestans collected during 1995-96 from different italian regions, 27 strains of mating type A2 e 7 strains of Self were identified. All the A2 and Self isolates from potato and tomato plants were
Cristinzio, Gennaro, Testa, Antonino
core +1 more source
Ischemic stroke is the most common cerebrovascular disease and the leading cause of permanent disability worldwide. Recent studies have shown that stroke development and prognosis are closely related to abnormal tryptophan metabolism.
Qun Wang +9 more
core +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Investigation of Neuropeptide Y as a metabolic marker and its effects on adipose vasculature and brainstem astrocytes [PDF]
, 2015 Subsets of morbidly obese patients do not appear to exhibit the expected comorbidities, as well as the fact that heightened sympathetic nervous system (SNS) activity has been known to affect metabolism.
Casale, C
core
British Journal of Pharmacology, EarlyView.The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral +3 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu +20 more
wiley +1 more source
Acta Anaesthesiologica Scandinavica, Volume 71, Issue 1, January 2027.ABSTRACT Background Detection of cerebral ischaemia is challenging in patients who are anaesthetised, sedated or have reduced levels of consciousness, as neurological examination is difficult or even impossible to assess. Furthermore, as some patients cannot be transported for radiology, for example during surgery, a reliable blood biomarker for ...
Richard Vithal +13 more
wiley +1 more source
Glia, Volume 74, Issue 12, December 2026.Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau +2 more
wiley +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, Volume 38, Issue 61, 2 November 2026.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity [PDF]
, 2003 Although the accumulation of the neurotoxic peptide {beta} amyloid ({beta}A) in the CNS is a hallmark of Alzheimer's disease, the mechanism of {beta}A neurotoxicity remains controversial.
Abramov, A.Y. +2 more
core