Results 241 to 250 of about 25,494 (296)
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Randomized Clinical Trials with Levosimendan
The American Journal of Cardiology, 2005There are important unmet needs in the treatment of acute heart failure syndromes (AHFS). The unique dual mechanism of action of levosimendan suggests that this new agent may help fill some of these unmet needs. A review of randomized, controlled clinical trials with levosimendan demonstrated that it is well tolerated, and its use results in ...
Alexandre, Mebazaa +2 more
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Veterinary Surgery, 1991
Randomized clinical trials were developed to eliminate biases inherent in clinical medicine. Six types of bias that can occur during patient selection and treatment allocation and in the collection and analysis of the data have been identified. A variation of the prospective randomized clinical trial, the nonrandomized surgeon design, overcomes biases ...
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Randomized clinical trials were developed to eliminate biases inherent in clinical medicine. Six types of bias that can occur during patient selection and treatment allocation and in the collection and analysis of the data have been identified. A variation of the prospective randomized clinical trial, the nonrandomized surgeon design, overcomes biases ...
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The CASSISS Randomized Clinical Trial
Stroke, 2023The CASSISS trial (China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis), recently published in JAMA , is the most recent of several randomized controlled trials that have failed to show a benefit of percutaneous angioplasty and stenting over medical therapy for the prevention of stroke due ...
Tanya N. Turan, Marios-Nikos Psychogios
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JAMA: The Journal of the American Medical Association, 1985
To the Editor.— I read with considerable interest the editorial by Dr Peter P. Morgan 1 entitled "Randomized Clinical Trials Need to be More Clinical." I was somewhat amazed with the author's comment that a "randomized clinical trial requires clinicians to set aside their own judgments, asks patients to accept treatment that may be substandard,..." I ...
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To the Editor.— I read with considerable interest the editorial by Dr Peter P. Morgan 1 entitled "Randomized Clinical Trials Need to be More Clinical." I was somewhat amazed with the author's comment that a "randomized clinical trial requires clinicians to set aside their own judgments, asks patients to accept treatment that may be substandard,..." I ...
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Randomized Clinical Trials in Melanoma
Surgical Oncology Clinics of North America, 2010The incidence of melanoma is increasing and it is estimated that, in the United States, the lifetime risk of developing melanoma is 1 in 55. There have been many randomized trials that have refined the treatment and minimized the morbidity of the intervention of this prevalent disease.
T Peter, Kingham +2 more
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The Ethics of Randomized Clinical Trials
Cancer Investigation, 1987Randomized clinical trials pose a number of fundamental ethical problems to which morally sensitive investigators must give careful consideration. The randomized double-blind clinical trial is ethically justified and the preferred method of demonstrating therapeutic effectiveness and safety.
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Adaptive Randomization for Clinical Trials
Journal of Biopharmaceutical Statistics, 2012In February 2010, the U.S. Food and Drug Administration (FDA, 2010 ) drafted guidance that discusses the statistical, clinical, and regulatory aspects of various adaptive designs for clinical trials. An important class of adaptive designs is adaptive randomization, which is considered very briefly in subsection VI.B of the guidance.
William F, Rosenberger +2 more
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Randomized clinical trials: Why not?
Controlled Clinical Trials, 1981Randomized clinical trials (RCT) are accepted by the scientific community throughout the world as the most desirable and most conclusive way to gain knowledge on drug efficacy. They have become as indispensable to medical science as are autopsies. Hill [1] and Martini [2] independently discussed the potential value of RCTs in the 1930s. Since then, the
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Randomized Clinical Trials in Melanoma
Surgical Oncology Clinics of North America, 2002Efforts to improve the survival of patients with metastatic melanoma have led to 67 prospective randomized clinical trials investigating the use of agents comprising three main areas of therapy: systemic chemotherapy-based regimens, immunotherapy, and vaccine ...
Kathryn, Spanknebel +4 more
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Randomized Clinical Trials in Surgery
International Journal of Technology Assessment in Health Care, 1989When it is well conducted, a randomized clinical provides the strongest evidence available for evaluating the comparative effectiveness of the interventions tested. Over the last two generations, we have learned much about various devices for strengthening them and about methods of avoiding between in their design, execution, analysis, and reporting ...
B, McPeek, F, Mosteller, M, McKneally
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