Results 31 to 40 of about 25,494 (296)

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam, Bara, Rebecca, Cotten, C Michael, Das, Abhik, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Garg, Meena, Higgins, Rosemary D, Keszler, Martin, Klein, Jonathan M, Lakshminrusimha, Satyan, Malian, Monica, Nelin, Leif D, Ohls, Robin, Saha, Shampa, Sanchez, Pablo J, Shankaran, Seetha, Sood, Beena G, Van Meurs, Krisa P, Wallace, Dennis   +18 more
core   +2 more sources

Ethical considerations in the design, execution, and analysis of clinical trials of chronic pain treatments

PAIN Reports, 2019
. Introduction:. In the field of pain research, clinical trials may randomize over 500 subjects and include more than 150 sites spanning over a dozen countries. Methods:.
Michael C. Rowbotham, Michael P. McDermott   +1 more
doaj   +1 more source

Ethical Challenges of Randomized Violence Intervention Trials: Examining the SHARE intervention in Rakai, Uganda. [PDF]

, 2016
ObjectiveWe identify complexities encountered, including unanticipated crossover between trial arms and inadequate 'standard of care' violence services, during a cluster randomized trial (CRT) of a community-level intimate partner violence (IPV) and HIV ...
Nalugoda, Fred, Namatovu, Fredinah, Paul, Amy, Ssekubugu, Robert, Wagman, Jennifer A   +4 more
core   +2 more sources

Minimization in randomized clinical trials

Statistics in Medicine, 2023
In randomized trials, comparability of the treatment groups is ensured through allocation of treatments using a mechanism that involves some random element, thus controlling for confounding of the treatment effect. Completely random allocation ensures comparability between the treatment groups for all known and unknown prognostic factors.
Elisabeth Coart, Perrine Bamps, Emmanuel Quinaux, Geneviève Sturbois, Everardo D. Saad, Tomasz Burzykowski, Marc Buyse   +6 more
openaire   +5 more sources

Assessing the Effect of Intrathecal Alfentanil in the Quality and Duration of Spinal Anesthesia in Cesarean Section and Side Effects: [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2010
Background and Objectives: The use of neuraxial opioids has gained popularity over the last few years; they may cause analgesia by the local anesthetic through direct binding with the specific spinal receptors.
Abedin Zadeh M.R., Rasti Brujeni M., Kheiri S   +2 more
doaj  

A method to reduce imbalance for site-level randomized stepped wedge implementation trial designs

Implementation Science, 2019
Background Controlled implementation trials often randomize the intervention at the site level, enrolling relatively few sites (e.g., 6–20) compared to trials that randomize by subject.
Robert A. Lew, Christopher J. Miller, Bo Kim, Hongsheng Wu, Kelly Stolzmann, Mark S. Bauer   +5 more
doaj   +1 more source

Active Clinical Trials for Personalized Medicine

, 2015
Individualized treatment rules (ITRs) tailor treatments according to individual patient characteristics. They can significantly improve patient care and are thus becoming increasingly popular.
Cheng, Guang, Minsker, Stanislav, Zhao, Ying-Qi   +2 more
core   +2 more sources

The CHOICE Randomized Clinical Trial

JACC: Cardiovascular Interventions, 2020
We read with interest the paper by Abdel-Wahab et al. ([1][1]) regarding the 5-year outcomes of the CHOICE trial (A Comparison of Transcatheter Heart Valves in High Risk Patients With Severe Aortic Stenosis: The CHOICE Trial).
Bisson, Arnaud, Fauchier, Laurent, Collart, Frederic, Cuisset, Thomas, Deharo, Pierre   +4 more
openaire   +3 more sources

Computer-Assisted versus Oral-and-Written History Taking for the Prevention and Management of Cardiovascular Disease: a Systematic Review of the Literature [PDF]

, 2017
Background and objectives: CVD is an important global healthcare issue; it is the leading cause of global mortality, with an increasing incidence identified in both developed and developing countries. It is also an extremely costly disease for healthcare
Auerbach, Bachman, Baer, Benaroia, Bowling, Bruce, Bulpitt, Chaudhry, Cohen, Dale, Davis, Farzanfar, Furlan, Galliher, Gill, Grizzle, Hivert, Hogan, Holbrook, Jaya, Lane, Lau, Liberati, Llewelyn, Lowensteyn, Lozano, Mayne, Pappas, Poissant, Quinn, Rogers, Ruffin, Sequist, Sequist, Sheridan, Sheridan, Sidorov, Slack, Slack, Sterne, Tang, Thompson, Turner, Wakefield, Wei, Wolford   +45 more
core   +5 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source