Results 31 to 40 of about 58,761 (268)

An exact solution of the higher-order gravity in standard radiation-dominated era

open access: yesPhysics Letters B, 2023
We report that the standard evolution of radiation-dominated era (RDE) universe a∝t1/2 is a sufficient condition for solving a sixth order gravitational field equation derived from the Lagrangian containing BRabRab+CRR;cc as well as a polynomial f(R) for
Chae-min Yun   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Periodic solutions with prescribed minimal period to Hamiltonian systems

open access: yesJournal of Inequalities and Applications, 2020
In this article, we study the existence of periodic solutions to second order Hamiltonian systems. Our goal is twofold. When the nonlinear term satisfies a strictly monotone condition, we show that, for any T > 0 $T>0$ , there exists a T-periodic ...
Huafeng Xiao, Zupei Shen
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

IMPACT OF HARDENING ON SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP DISPLACEMENT UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2015
In this article,elastic-plastic curved crack tip opening displacement in hardened material under quasi-static loads has been mainly studied,and curved crack tip opening displacement has been calculated as a practical application of a second order ...
YANG DaPeng   +4 more
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Decomposition–Linearization–Sequential Homotopy Methods for Nonlinear Differential/Integral Equations

open access: yesMathematics
In the paper, two new analytic methods using the decomposition and linearization technique on nonlinear differential/integral equations are developed, namely, the decomposition–linearization–sequential method (DLSM) and the linearized homotopy ...
Chein-Shan Liu   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

IMPACT OF HARDENING ON J INTEGRAL AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

open access: yesJixie qiangdu, 2016
J integral of elastic-plastic curved crack in hardened material under quasi-static loads has been mainly studied,and curved crack tip J integral has been calculated as a practical application of a second order perturbation method and theorem of surname ...
YANG DaPeng   +3 more
doaj  

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