Results 51 to 60 of about 61,137 (267)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

In-Plane Stability of Circular Arch Under Uniform Vertical Load Based on the Asymptotic Method

Buildings
Conventional analyses often simplify vertical loads as uniform radial loads while neglecting axial force effects in the buckling analyses of arches, leading to discrepancies between theoretical predictions and actual loading conditions.
Jing Jin, Mingzhou Su
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

On the high-order topological asymptotic expansion for shape functions

Electronic Journal of Differential Equations, 2016
This article concerns the topological sensitivity analysis for the Laplace operator with respect to the presence of a Dirichlet geometry perturbation. Two main results are presented in this work.
Maatoug Hassine, Khalifa Khelifi
doaj  

Weak cosmic censorship conjecture in Einstein–Maxwell gravity with scalar hair

European Physical Journal C: Particles and Fields, 2020
In this paper, we focus on the weak cosmic censorship conjecture (WCCC) in the Einstein–Maxwell gravity sourced by a conformally coupled scalar field, where the black hole solution can carry a scalar hair apart from the conserved charges of the ...
Jie Jiang, Ming Zhang
doaj   +1 more source

Leading all-loop quantum contribution to the effective potential in general scalar field theory

Journal of High Energy Physics, 2023
The RG equation for the effective potential in the leading log (LL) approximation is constructed which is valid for an arbitrary scalar field theory in 4 dimensions.
D. I. Kazakov, R. M. Iakhibbaev, D. M. Tolkachev   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Existence and Uniqueness of Exact WKB Solutions for Second-Order Singularly Perturbed Linear ODEs

Communications in Mathematical Physics, 2023
AbstractWe prove an existence and uniqueness theorem for exact WKB solutions of general singularly perturbed linear second-order ODEs in the complex domain. These include the one-dimensional time-independent complex Schrödinger equation. Notably, our results are valid both in the case of generic WKB trajectories as well as closed WKB trajectories.
openaire   +3 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source