Results 51 to 60 of about 493,106 (301)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Single-layer solutions for the Dirichlet problem for a quasilinear singularity perturbed second order system

Rocky Mountain Journal of Mathematics, 1988
Consider the second-order system with the Dirichlet boundary conditions: \[ (*)\quad \frac{d^ 2}{dt^ 2}=F(t,x,\epsilon)\frac{dx}{dt}+g(t,x,\epsilon),\quad for\quad ...
openaire   +3 more sources

IMPACT OF HARDENING ON J INTEGRAL AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

Jixie qiangdu, 2016
J integral of elastic-plastic curved crack in hardened material under quasi-static loads has been mainly studied,and curved crack tip J integral has been calculated as a practical application of a second order perturbation method and theorem of surname ...
YANG DaPeng, WANG JunJie, ZHAO Yao, LI TianYun   +3 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPACT OF HARDENING ON PLASTICITY AREA AT THE SLIGHTLY CURVED ELASTICITY-PLASTICITY CRACK TIP UNDER QUASI-STATIC LOADS

Jixie qiangdu, 2015
In this article,elastic-plastic curved crack tip plasticity area in hardened material under quasi-static loads has been mainly studied,and curved crack tip plasticity area has been calculated as a practical application of a second order perturbation ...
YANG DaPeng, WANG JianXun, ZHAO Yao
doaj  

A new extended (2+1)-dimensional Kadomtsev–Petviashvili equation with N-solitons, periodic solutions, rogue waves, breathers and lump waves

Results in Physics, 2022
In this work, a new extended integrable (2+1)-dimensional Kadomtsev–Petviashvili equation is proposed and investigated, which models slowly varying perturbation wave in dispersion fluids.
Lingfei Li, Yingying Xie, Yongsheng Yan, Mancang Wang   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

ASYMPTOTICS OF THE SOLUTION OF THE FIRST BOUNDARY VALUE PROBLEM FOR A SINGULARLY PERTURBED DIFFERENTIAL EQUATION IN PARTIAL DERIVATIVES OF THE SECOND ORDER OF PARABOLIC TYPE

Bulletin of the South Ural State University series "Mathematics. Mechanics. Physics", 2022
The article constructs a complete uniform asymptotic expansion in a small parameter of the solution of the first boundary value problem. The first boundary value problem is posed for a singularly perturbed linear inhomogeneous second-order partial differential equation with two independent variables of parabolic type.
K.G. Kozhobekov, A.A. Shоorukov, D.A. Tursunov   +2 more
openaire   +2 more sources

In-Plane Stability of Circular Arch Under Uniform Vertical Load Based on the Asymptotic Method

Buildings
Conventional analyses often simplify vertical loads as uniform radial loads while neglecting axial force effects in the buckling analyses of arches, leading to discrepancies between theoretical predictions and actual loading conditions.
Jing Jin, Mingzhou Su
doaj   +1 more source

Minimum-length deformed quantization of a free field on de Sitter background and corrections to the inflaton perturbations

, 2012
The effect of string and quantum gravity inspired minimum-length deformed quantization on a free, massless scalar field is studied on de Sitter background at the level of second quantization. Analytic solution of a field operator is obtained to the first
Maziashvili, Michael
core   +1 more source