Results 81 to 90 of about 61,137 (267)

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Asymptotic perturbation and sensitivity analysis of malaria transmission in Nigeria: a mathematical model

Recent Advances in Natural Sciences
This article analyzes malaria dynamics among high-risk groups in Nigeria, with the human population divided into five compartments and the mosquito population divided into two compartments.
Sunday N. Aloke, Henry O. Adagba, Uchenna E. Michael, Okorie Nwite, Theresa E. Efor, Aloysius N. Ezaka, Chika Agha   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

New spectral element method for the singular perturbation problem of second order

上海师范大学学报. 自然科学版
As the solution of singular perturbation problem of second order has a boundary layer, it is difficult to obtain ideal approximation results for traditional numerical methods.
LIU Zhipeng, TAO Dongya
doaj   +1 more source

Drag flow analysis of Oldroyd eight constant fluid

Alexandria Engineering Journal, 2016
This article presents the steady drag flow problems. The incompressible Oldroyd eight constant fluid flow is considered between two infinite parallel plates.
A.M. Siddiqui, A. Sohail, A. Ashraf, Q.A. Azim   +3 more
doaj   +1 more source

On the Sublinear Convergence of Randomly Perturbed Alternating Gradient Descent to Second Order Stationary Solutions

CoRR, 2018
The alternating gradient descent (AGD) is a simple but popular algorithm which has been applied to problems in optimization, machine learning, data ming, and signal processing, etc. The algorithm updates two blocks of variables in an alternating manner, in which a gradient step is taken on one block, while keeping the remaining block fixed.
Lu, Songtao, Hong, Mingyi, Wang, Zhengdao   +2 more
openaire   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Existence of solutions to second-order boundary-value problems with small perturbations of impulses

Electronic Journal of Differential Equations, 2013
Summary: We study second-order impulsive differential equations with Dirichlet boundary conditions, depending on two real parameters. We show that an appropriate growth condition of the nonlinear term, under small perturbations of impulsive terms, ensures the existence of three solutions. The approach is based on variational methods.
BONANNO, Gabriele, DI BELLA, Beatrice, Henderson, J.   +2 more
openaire   +3 more sources

Preservation of nonoscillatory behavior of solutions of second-order delay differential equations under impulsive perturbations

Applied Mathematics Letters, 2002
Here, the authors present a new criterion for the preservation of nonoscillatory behavior of solutions to the second-order delay differential equation \[ x''(t) + p(t) x(t-\tau)=0,\qquad t\geq t_0, \] under impulsive perturbations. A method of direct analysis and a technique not utilizing fixed-point theorems are developed.
Mingshu Peng, Weigao Ge, Qianli Xu
openaire   +2 more sources