Results 151 to 160 of about 234,152 (246)

Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin. [PDF]

, 2019
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor.
Blanchard, Scott C, Canty, John T, Elshenawy, Mohamed M, Ferro, Luke S, Oster, Liya, Yildiz, Ahmet, Zhou, Zhou   +6 more
core  

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Nature Communications, 2016
The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during replication, a process that requires the ATPase-dependent activity of the MCM complex. Using cryo-EM reconstructions of the CMG complex in different conformations, the authors propose a model where the
Ferdos Abid Ali, Ludovic Renault, Julian Gannon, Hailey L. Gahlon, Abhay Kotecha, Jin Chuan Zhou, David Rueda, Alessandro Costa   +7 more
doaj   +1 more source

Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. [PDF]

, 1993
A polymerase chain reaction strategy was devised to identify new members of the mammalian myosin I family of actin-based motors. Using cellular RNA from mouse granular neurons and PC12 cells, we have cloned and sequenced three 1.2-kb polymerase chain ...
Greene, LA, Joyce, MP, Sherr, EH
core  

Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]

, 2020
The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core  

The structural basis for enhancer-dependent assembly and activation of the AAA transcriptional activator NorR [PDF]

, 2015
Bates, PA, Bush, M, Dixon, R, Ghosh, T, Moal, IH, Sawicka, M, Zhang, X   +6 more
core   +1 more source

Spa47 is an oligomerization-activated type three secretion system (T3SS) ATPase from \u3cem\u3eShigella flexneri\u3c/em\u3e [PDF]

, 2016
Gram-negative pathogens often use conserved type three secretion systems (T3SS) for virulence. The Shigella type three secretion apparatus (T3SA) penetrates the host cell membrane and provides a unidirectional conduit for injection of effectors into host
Antony, Edwin, Burgess, Jamie L., Dickenson, Nicholas E., Jones, Heather B., Kumar, Prashant, Middaugh, C. Russell, Toth IV, Ronald T.   +6 more
core   +1 more source

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. [PDF]

, 2019
Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubilizing protein aggregates.
Bart, Stephen M, Castellano, Laura M, DiMaio, Frank, Gates, Stephanie N, Lin, JiaBei, Rizo, Alexandrea N, Shorter, James, Southworth, Daniel R, Tse, Eric   +8 more
core  

Bridging the gap by AAA ATPases [PDF]

Nature, 1997
Tony Rowe, William E. Balch
openaire   +1 more source

The AAA-ATPase Yta4/ATAD1 interacts with the mitochondrial divisome to inhibit mitochondrial fission. [PDF]

PLoS Biol, 2023
He J, Liu K, Wu Y, Zhao C, Yan S, Chen JH, Hu L, Wang D, Zheng F, Wei W, Xu C, Huang C, Liu X, Yao X, Ding L, Fang Z, Tang AH, Fu C.   +17 more
europepmc   +1 more source

Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis. [PDF]

mBio, 2023
Pan S, Jensen AA, Wood NA, Henrichfreise B, Brötz-Oesterhelt H, Fisher DJ, Sass P, Ouellette SP.   +7 more
europepmc   +1 more source