Results 41 to 50 of about 5,035,811 (266)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Gürcü Rüyası Partisi: “Yabancı Ajan” Yasa Tasarısının AB ile İlişkiler Kapsamında Değerlendirilmesi
Akademik İncelemeler DergisiKüresel düzenin “soğuk” büyük güçlerinden olan SSCB 1991’de resmen dağıldığında siyaset bilimi akademisi, post komünist devletlerde başlayan demokratikleşme sürecinin heyecanıyla liberal siyasetin zaferini ilan ettiler.
Seda Kaya Karabulut
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesBackground: The newer concept of A-BA is gaining more and more attention as newer smart dental material helps in rebuilding demineralized dentin. Aim: To evaluate ABE, HA-CG, FR, and ML in BA restorative material.
Sonali Waghmode +5 more
doaj +1 more source
Variational Principles for Natural Divergence-free Tensors in Metric Field Theories
, 2012 Let $T^{ab}=T^{ba}=0$ be a system of differential equations for the components of a metric tensor on $R^m$. Suppose that $T^{ab}$ transforms tensorially under the action of the diffeomorphism group on metrics and that the covariant divergence of $T^{ab}$
Aldersley +31 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Arap Baharı Sonrası Avrupa Birliği'nin Yeni Komşuluk Politikasi
Mukaddime, 2018 Özet Orta Doğu ve Kuzey Afrika’da 2010 yılında ortaya çıkan halk isyan dalgaları, AB’nin Güney Akdeniz ülkeleriyle ilişkilerini komşuluk politikası bağlamında yeniden düzenlemesine neden olmuştur.
Zelal Başak Kızılkan
doaj +1 more source
Low-temperature electrical transport in bilayer manganite La$_{1.2}$Sr$_{1.8}$Mn$_{2}$O$_{7}$
, 2002 The temperature $T$ and magnetic field $H$ dependence of anisotropic in-plane $\rho_{ab}$ and out-of-plane $\rho_{c}$ resistivities have been investigated in single crystals of the bilayer manganite La$_{1.2}$Sr$_{1.8}$Mn$_{2}$O$_{7}$.
A.A. Abrikosov +41 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Kerr-Schild metrics revisited II. The complete vacuum solution
, 2002 The complete solution of Einstein's gravitational equations with a vacuum-vacuum Kerr-Schild pencil of metrics $g_{ab}+V l_al_b$ is obtained. Our result generalizes the solution of the Kerr-Schild problem with a flat metric $g_{ab}$ (represented by the ...
László Á. Gergely +2 more
core +1 more source