Results 81 to 90 of about 5,075,322 (256)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Thermoelectric effects of an Aharonov-Bohm interferometer with an embedded quantum dot in the Kondo regime

, 2003
Thermoelectric effects are studied in an Aharonov-Bohm (AB) interferometer with an embedded quantum dot in the Kondo regime. The AB flux-dependent transmission probability has an asymmetrical shape arising from the Fano interference between the direct ...
A. Yacoby, B.R. Bulka, D. Goldhaber-Gordon, D.C. Langreth, D.L. Cox, E. Kim, G.D. Guttman, J. Göres, J. Li, J. Nygard, K. Kobayashi, K. Yamada, K. Yamada, L.I. Glazman, L.V. Keldysh, M.H. Hettler, M.V. Moskalets, N.C. Manoharan, N.E. Bickers, N.E. Bickers, N.S. Wingreen, R. Schuster, S. Hershfield, S.M. Cronenwett, T.-S. Kim, T.-S. Kim, T.-S. Kim, T.-S. Kim, T.K. Ng, T.W. Odom, Tae-Suk Kim, Th. Pruschke, U. Sivan, V. Madhavan, W. Hofstetter, Y. Ji, Y. Ji, Y. Meir, Ya.M. Blanter   +38 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Last Ten Years of Civil Society in the European Union and Turkey: Discussions on the Tightening of Civic Space

İstanbul Gelişim Üniversitesi Sosyal Bilimler Dergisi
When the Justice and Development Party (AKP) came first into power in 2002, in line with the European Union (EU) membership goals, it initiated a reform, democratization and Europeanization process.
Nihan Akıncılar Köseoğlu, Şirin Duygulu Elcim   +1 more
doaj   +1 more source

Systematic behaviour of the in-plane penetration depth in d-wave cuprates

, 1997
We report the temperature T and oxygen concentration dependences of the penetration depth of grain-aligned YBa_2Cu_3O_{7-\delta} with \delta= 0.0, 0.3 and 0.43. The values of the in-plane \lambda_{ab}(0) and out-of-plane \lambda_{c}(0) penetration depths,
A. Carrington, A. Porch, C. K. Subramaniam, C. Panagopoulos, C. Panagopoulos, C. Panagopoulos, C. Panagopoulos, C. Panagopoulos, D. A. Bonn, D. Broun, D. Shoenberg, G. B. Peacock, J. Chrosch, J. L. Tallon, J. L. Wagner, J. L. Wagner, J. M. Harris, J. R. Cooper, J. R. Kirtley, J. W. Loram, K. Maki, M. Oda, N. Athanassopoulou, P. A. Lee, Q. Xiong, R. Beyers, S. F. Lee, T. Jakobs, T. Xiang, T. Xiang, T. Xiang, W. N. Hardy, Y. J. Uemura   +32 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The Chance in the Balance of Power in the Transatlantic Structure in the 21st Century

İstanbul Gelişim Üniversitesi Sosyal Bilimler Dergisi
With the end of the bipolar structure, the power vacuum that arose in the international structure was replaced by the United States, and the United States became a state that directs and shapes the international system. Within the transatlantic alliance,
Seda Gözde Tokatlı
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source