Abacavir-induced liver toxicity [PDF]
Brazilian Journal of Infectious Diseases, 2016 Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen ...
Cristina Gervasoni +2 more
exaly +4 more sources
Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity? [PDF]
Frontiers in Pharmacology, 2021 The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated.
Víctor Collado-Díaz +15 more
doaj +2 more sources
Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses. [PDF]
PLoS ONE, 2014 Abacavir hypersensitivity is a severe hypersensitivity reaction which occurs exclusively in carriers of the HLA-B*57∶01 allele. In vitro culture of PBMC with abacavir results in the outgrowth of abacavir-reacting CD8+ T cells, which release IFNγ and are ...
Jacqueline Adam +8 more
doaj +3 more sources
Relaxation effect of abacavir on rat basilar arteries. [PDF]
PLoS ONE, 2015 BackgroundThe use of abacavir has been linked with increased cardiovascular risk in patients with human immunodeficiency virus infection; however, the mechanism involved remains unclear. We hypothesize that abacavir may impair endothelial function.
Rachel Wai Sum Li +6 more
doaj +3 more sources
Acute myocardial infarction associated with abacavir and tenofovir based antiretroviral drug combinations in the United States [PDF]
AIDS Research and Therapy, 2021 Introduction Although individual antiretroviral drugs have been shown to be associated with elevated cardiovascular disease (CVD) risk, data are limited on the role of antiretroviral drug combinations.
Kunchok Dorjee +5 more
doaj +2 more sources
Abacavir safety and effectiveness in young infants with HIV in South African observational cohorts [PDF]
Antiviral Therapy, 2023 Background WHO guidelines recommend abacavir in first-line antiretroviral treatment for children and neonates. However, there is no approved dose
Reneé de Waal +12 more
doaj +3 more sources
Abacavir-reactive memory T cells are present in drug naïve individuals.
PLoS ONE, 2015 BackgroundFifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug.
Andrew Lucas +15 more
doaj +2 more sources
Replication Stress Tolerance in Adult T-Cell Leukemia [PDF]
BiomoleculesReplication stress (RS) represents a major vulnerability of cancer cells treated with nucleoside analogs and related antimetabolites; however, tumors frequently acquire tolerance mechanisms that permit survival despite persistent DNA lesions. This review
Yusuke Okamoto +4 more
doaj +2 more sources
The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome [PDF]
Scientific Reports, 2019 Abacavir is an antiretroviral drug used to reduce human immunodeficiency virus (HIV) replication and decrease the risk of developing acquired immune deficiency syndrome (AIDS).
James Fodor +4 more
doaj +2 more sources
The Influence of Plasma and Peritoneal Antiretroviral Drugs Levels on the Shedding of HIV-1 Into Peritoneal Dialysis Effluent. [PDF]
J Med VirolABSTRACT Penetrance of antiretroviral therapy in the peritoneal cavity and its influence on the shedding of HIV‐1 into continuous ambulatory peritoneal dialysis (CAPD) was investigated. This prospective cross‐sectional study of HIV‐positive end‐stage kidney failure (ESKF) patients managed with ART and CAPD, collected enrolled patients' demographic ...
Mooko T +8 more
europepmc +2 more sources