Results 1 to 10 of about 20,756 (118)
The study on the transport and phosphorylation kinetics of zidovudine in the Chinese population and its significance for individualized antiretroviral therapy [PDF]
Scientific ReportsZidovudine (AZT), a nucleoside reverse transcriptase inhibitor, exerts its antiviral effect through intracellular conversion to AZT-triphosphate (AZT-TP), with therapeutic efficacy and toxicity closely linked to intracellular AZT-TP levels rather than ...
Fang Tang +4 more
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Pharmaceutics, 2022 Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are the backbone of HIV antiretroviral therapy (ART). ART use in pregnancy has been associated with adverse birth outcomes, in part due to NRTI-induced mitochondrial toxicity.
Kayode Balogun, Lena Serghides
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Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?
Cells, 2021 After the introduction of antiretroviral treatment (ART) back in 1996, the lifespan of people living with HIV (PLWH) has been substantially increased, while the major causes of morbidity and mortality have switched from opportunistic infections and AIDS ...
Athanasios-Dimitrios Bakasis +1 more
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The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy
Molecules, 2022 The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug).
Maria da Conceição Avelino Dias Bianco +6 more
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Post Exposure Prophylaxis for Occupational Exposures to HIV and Hepatitis B: Our Experience of Thirteen Years at a Rural Based Tertiary Care Teaching Hospital of Western India [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Health Care Workers (HCWs) are at risk of occupational transmission of HIV, Hepatitis B and Hepatitis C, which can be minimized by following guidelines for standard precautions as well as taking Post Exposure Prophylaxis (PEP) measures.
Sanket Pranjivan Sheth +2 more
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Frontiers in Microbiology, 2022 Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live ...
Qun Wang +29 more
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Perinatal HIV and Neurodevelopment
Pediatric Neurology Briefs, 1994 The natural history of HIV disease and neurodevelopmental disorders in 21 perinatally infected children were examined in a collaborative prospective study sponsored by the National Institute of Child Health & Human Development, Rockville, MD.
J Gordon Millichap
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Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats
Journal of Nanotechnology, 2014 Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as ...
Shah Purvin +4 more
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Frontiers in Pharmacology, 2018 Aim: Zidovudine and tenofovir form the backbone of antiretroviral therapy in Kenya. However, their side-effects may affect the quality of life (QoL) of patients.
Jilian O. Etenyi +16 more
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Nano Co-Crystal Embedded Stimuli-Responsive Hydrogels: A Potential Approach to Treat HIV/AIDS
Pharmaceutics, 2021 Currently, the human immunodeficiency virus (HIV) that causes acquired immunodeficiency syndrome (AIDS) can only be treated successfully, using combination antiretroviral (ARV) therapy.
Bwalya A. Witika +3 more
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