Results 1 to 10 of about 60,681 (284)

Enhanced Antiviral Ability by a Combination of Zidovudine and Short Hairpin RNA Targeting Avian Leukosis Virus [PDF]

Frontiers in Microbiology, 2022
Avian leukosis virus (ALV) causes tumor diseases in poultry and is circulating all over the world, leading to significant economic losses. In addition, mixed infection of ALV with other viruses is very common and is often reported to contaminate live ...
Qun Wang, Qun Wang, Qun Wang, Qi Su, Qi Su, Qi Su, Bowen Liu, Bowen Liu, Bowen Liu, Yan Li, Yan Li, Yan Li, Wanli Sun, Wanli Sun, Wanli Sun, Yanxue Liu, Yanxue Liu, Yanxue Liu, Ruyu Xue, Ruyu Xue, Ruyu Xue, Shuang Chang, Shuang Chang, Shuang Chang, Yixin Wang, Yixin Wang, Yixin Wang, Peng Zhao, Peng Zhao, Peng Zhao   +29 more
doaj   +2 more sources

Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway [PDF]

Cell Death and Disease, 2015
Pancreatic cancer is one of the most difficult malignancies to treat owing to the rapid acquisition of resistance to chemotherapy. Gemcitabine, a first-line treatment for pancreatic cancer, prolongs patient survival by several months, and combination ...
Takushi Namba, R. Kodama, S. Moritomo, Tatsuya Hoshino, T. Mizushima   +4 more
semanticscholar   +2 more sources

Reversed phase HPLC determination of zidovudine in rat plasma and its pharmacokinetics after a single intranasal dose administration [PDF]

Biological Research, 2009
The development and validation of a simple and accurate method based on HPLC with ultraviolet detection for the quantification of zidovudine in rat plasma and its application to a pharmacokinetic study following a single intranasal dose zidovudine is ...
RUBIANA M MAINARDES, MARIA PALMIRA D. GREMIÃO   +1 more
doaj   +2 more sources

Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

Journal of Nanotechnology, 2014
Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as ...
Shah Purvin, Parameswara Rao Vuddanda, Sanjay Kumar Singh, Achint Jain, Sanjay Singh   +4 more
doaj   +2 more sources

Probiotic Bacillus subtilis, but Not a Lactobacillus spp., Ameliorates Cognitive Impairment in a Mouse Model of LPS and Zidovudine-Induced Neuroinflammation [PDF]

Brain Sciences
Background/Objectives: The gut–brain axis is increasingly recognized as a critical modulator of cognitive function. This study investigated the neurotoxic effects of combined exposure to bacterial lipopolysaccharide (LPS) and the antiretroviral drug ...
Olga Murgina, Ksenia Stafeeva, Sofya Karaulova, Alena Vostrikova, Sofya Kononova, Daria Chursina, Svetlana Pozdeeva, Anastasia Makogonova, Inna Burakova, Svetlana Pogorelova, Polina Morozova, Yulia Smirnova, Mikhail Syromyatnikov, Viktor Shutikov, Evgeny Mikhailov, Artem Gureev   +15 more
doaj   +2 more sources

Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV.

New England Journal of Medicine, 2021
BACKGROUND The World Health Organization recommends dolutegravir with two nucleoside reverse-transcriptase inhibitors (NRTIs) for second-line treatment of human immunodeficiency virus type 1 (HIV-1) infection. Evidence is limited for the efficacy of this
Nicholas I. Paton, J. Musaazi, C. Kityo, S. Walimbwa, A. Hoppe, Apolo Balyegisawa, A. Kaimal, G. Mirembe, Phionah Tukamushabe, Gilbert Ategeka, J. Hakim, H. Mugerwa, A. Siika, Jesca Asienzo, B. Castelnuovo, A. Kiragga, A. Kambugu   +16 more
semanticscholar   +1 more source

Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial.

The Lancet HIV, 2022
BACKGROUND WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine.
N. Paton, J. Musaazi, C. Kityo, S. Walimbwa, A. Hoppe, Apolo Balyegisawa, Jesca Asienzo, A. Kaimal, G. Mirembe, A. Lugemwa, Gilbert Ategeka, M. Borok, H. Mugerwa, A. Siika, E. L. Odongpiny, B. Castelnuovo, A. Kiragga, A. Kambugu, D. Kiiza, J. Kisembo, J. Nsubuga, Max Okwero, R. Muyise, Claire Nasaazi, D. Nakiboneka, J. Namusanje, Theresa Najjuuko, Timothy Masaba, T. Serumaga, Adolf Alinaitwe, Allan Arinda, A. Rweyora, Mary Goretti Kangah, M. Kasozi, Phionah Tukumushabe, Rogers Akunda, S. Makumbi, Sharif Musumba, Sula Myalo, John Ahuura, A. Namusisi, Daniel Kibirige, Francis Kiweewa, Habert Mabonga, Joseph Wandege, Josephine Nakakeeto, Sharon Namubiru, Winfred Nansalire, A. Siika, C. Kwobah, C. Mboya, M. Mokaya, M. Karoney, P. Cheruiyot, S. Cherutich, S. Njuguna, V. Kirui, E. Chidziva, G. Musoro, J. Hakim, J. Bhiri, M. Phiri, S. Mudzingwa, Tadios Manyanga, Anchilla Banegura, Betty Agwang, Brian Isaaya, Constantine Tumwine, E. L. Odongpiny, N. Paton, Peter Senkungu, Yvonne Kamara, Mathius Amperiize, Elizabeth Allen, C. Opondo, Perry Mohammed, Willemijn van Rein-van der Horst, Y. van Delft, F. A. Boateng, Doreen Namara, P. Kaleebu, S. Ojoo, T. Bwakura, Milly Katana, F. Venter, S. Phiri, S. Walker   +86 more
semanticscholar   +1 more source

Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model

Pharmaceutics, 2022
Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are the backbone of HIV antiretroviral therapy (ART). ART use in pregnancy has been associated with adverse birth outcomes, in part due to NRTI-induced mitochondrial toxicity.
Kayode Balogun, Lena Serghides
doaj   +1 more source

Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?

Cells, 2021
After the introduction of antiretroviral treatment (ART) back in 1996, the lifespan of people living with HIV (PLWH) has been substantially increased, while the major causes of morbidity and mortality have switched from opportunistic infections and AIDS ...
Athanasios-Dimitrios Bakasis, Theodoros Androutsakos   +1 more
doaj   +1 more source

The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

Molecules, 2022
The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug).
Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos   +6 more
doaj   +1 more source