Results 1 to 10 of about 27,793 (201)

The study on the transport and phosphorylation kinetics of zidovudine in the Chinese population and its significance for individualized antiretroviral therapy [PDF]

Scientific Reports
Zidovudine (AZT), a nucleoside reverse transcriptase inhibitor, exerts its antiviral effect through intracellular conversion to AZT-triphosphate (AZT-TP), with therapeutic efficacy and toxicity closely linked to intracellular AZT-TP levels rather than ...
Fang Tang, Shan Ji, Xiujun Lai, Tao Yan, Jie Peng   +4 more
doaj   +2 more sources

Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats [PDF]

Journal of Nanotechnology, 2014
Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as ...
Shah Purvin, Parameswara Rao Vuddanda, Sanjay Kumar Singh, Achint Jain, Sanjay Singh   +4 more
doaj   +2 more sources

Zidovudine/lamivudine for HIV-1 infection contributes to limb fat loss. [PDF]

PLoS ONE, 2009
Lipoatrophy is known to be associated with stavudine as part of the treatment for HIV infection, but it is less clear if this serious side effect is also related to other nucleoside reverse transcriptase inhibitors like zidovudine.
Marit G A van Vonderen, Michiel A van Agtmael, Elly A M Hassink, Ana Milinkovic, Kees Brinkman, Suzanne E Geerlings, Matti Ristola, Arne van Eeden, Sven A Danner, Peter Reiss, MEDICLAS study group   +10 more
doaj   +2 more sources

Development and validation of a normal-phase HPTLC method for the simultaneous analysis of Lamivudine and Zidovudine in fixed-dose combination tablets

Journal of Pharmaceutical Analysis, 2012
Simultaneous quantification of Lamivudine and Zidovudine in tablets by HPTLC method was developed and validated. The chromatograms were developed using a mobile phase of toluene:ethyl acetate:methanol (4:4:2, v/v/v) on pre-coated plate of silica gel GF ...
Palani Venkatesh, Mahesh Daggumati
exaly   +3 more sources

Mutations in HIV-1 reverse transcriptase during therapy with abacavir, lamivudine and zidovudine in HIV-1-infected adults with no prior antiretroviral therapy

, 2002
Objective: To evaluate HIV-1 reverse transcriptase (RT) drug resistance in patients receiving abacavir, lamivudine and zidovudine therapy. Methods: In a randomized, double-blind study, 173 antiretroviral treatment-naive HIV-1-infected adults received ...
Pulido Ortega, Federico, Lafon, Steve, Ait-Khaled, Mounir, Rubio García, Rafael   +3 more
core   +6 more sources

Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model

Pharmaceutics, 2022
Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are the backbone of HIV antiretroviral therapy (ART). ART use in pregnancy has been associated with adverse birth outcomes, in part due to NRTI-induced mitochondrial toxicity.
Kayode Balogun, Lena Serghides
doaj   +1 more source

Liver Fibrosis during Antiretroviral Treatment in HIV-Infected Individuals. Truth or Tale?

Cells, 2021
After the introduction of antiretroviral treatment (ART) back in 1996, the lifespan of people living with HIV (PLWH) has been substantially increased, while the major causes of morbidity and mortality have switched from opportunistic infections and AIDS ...
Athanasios-Dimitrios Bakasis, Theodoros Androutsakos   +1 more
doaj   +1 more source

The Use of Zidovudine Pharmacophore in Multi-Target-Directed Ligands for AIDS Therapy

Molecules, 2022
The concept of polypharmacology embraces multiple drugs combined in a therapeutic regimen (drug combination or cocktail), fixed dose combinations (FDCs), and a single drug that binds to different targets (multi-target drug).
Maria da Conceição Avelino Dias Bianco, Debora Inacio Leite, Frederico Silva Castelo Branco, Nubia Boechat, Elisa Uliassi, Maria Laura Bolognesi, Monica Macedo Bastos   +6 more
doaj   +1 more source

Impact of HIV Infection and Zidovudine Therapy on RBC Parameters and Urine Methylmalonic Acid Levels [PDF]

, 2016
Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA ...
Ebele Uche, Vincent Osunkalu, Tamunomieibi Wakama, Adewumi Adediran, Sarah John-Olabode, Akinsegun Akinbami, Sulaimon Akanmu, Uche, E., John-Olabode, S., Adediran, A., Wakama, T., Akanmu, S., Akinbami, A., Osunkalu, V.   +13 more
core   +3 more sources

Lenacapavir initiation with concomitant primidone: A case report with therapeutic drug monitoring. [PDF]

Br J Clin Pharmacol
Lenacapavir (LEN), a first‐in‐class capsid inhibitor, has unique pharmacokinetics that enable twice‐yearly dosing. LEN is not extensively metabolized, although it is a substrate of CYP3A4, which introduces drug–drug interactions concerns. As adoption and implementation of LEN for treatment and prevention increase, additional guidance on concomitant ...
Devanathan AS, Glowa T, Thompson EM, Saylor AJ, Nolin TD, Riddler SA, Ho KS.   +6 more
europepmc   +2 more sources