Results 21 to 30 of about 20,825 (172)

Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)

Brazilian Journal of Medical and Biological Research, 2000
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi ...
A. Poli-Neto, K. Nonoyama, M. Oshiro, W. Ebner-Filho, K. Miguita, T.M.D. Medeiros, C.I. Watanabe, O.C.O. Barretto   +7 more
doaj   +1 more source

Inhibition of UGT2B7 Enzyme Activity in Human and Rat Liver Microsomes by Herbal Constituents

Molecules, 2018
The co-use of conventional drug and herbal medicines may lead to herb-drug interaction via modulation of drug-metabolizing enzymes (DMEs) by herbal constituents.
Nurul Huda Abdullah, Sabariah Ismail
doaj   +1 more source

Refractory anemia in human immunodeficiency virus: Expect the unexpected

Journal of Family Medicine and Primary Care, 2016
Pure red cell aplasia (PRCA) is an uncommon hematological disorder affecting selectively the erythroid cell lines. PRCA is defined as anemia with normal leukocyte and platelet counts, a corrected reticulocyte count
Sumeet Prakash Mirgh, Vikas A Mishra, Virti D Shah, Jehangir Soli Sorabjee   +3 more
doaj   +1 more source

Comparison of Preterm Delivery Rates between HIV-infected Pregnant Women Receiving Highly Active Antiretroviral Therapy (HAART) Containing Protease Inhibitors (PIs) and HIV-infected Pregnant Women Receiving Zidovudine Monotherapy

Thai Journal of Obstetrics and Gynaecology, 2015
Objective:To compare the preterm delivery rates between pregnant women receiving HAART containing protease inhibitors (HAART-PIs) and zidovudine monotherapy (ZDVm) during pregnancy.Materials and Methods: A retrospective study was ...
Bongkot Chakornbandit, Fuanglada Tongprasert   +1 more
doaj   +1 more source

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD DETERMINATION OF ZIDOVUDINE ENCAPSULATED IN PCL NANOPARTICLES

Drug Analytical Research, 2017
A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for the determination of encapsulation efficiency of zidovudine in nanoparticules. The method was carried out in isocratic mode using 0.040M sodium acetate:
Milena Cristina Ribeiro Souza Magalhães, Alisson Samuel Portes Caldeira, Hanna de Sousa Rocha Almeida, Sílvia Ligório Fialho, Armando da Silva Cunha Junior   +4 more
doaj   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Idiopathic intracranial hypertension associated with anaemia, secondary to antiretroviral drug in a human immunodeficiency virus positive patient

Indian Journal of Ophthalmology, 2018
Papilledema in a patient with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome is an alarming finding. Any condition giving rise to raised intracranial tension (ICT) can cause papilledema, and in these patients, it could be ...
J Vijay Ananth, S Sudharshan, Ambika Selvakumar, Bella J Devaleenal, Kavitha Kalaivani, Jyotirmay Biswas   +5 more
doaj   +1 more source

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, EarlyView.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Top-Down Synthesis of a Lamivudine-Zidovudine Nano Co-Crystal

Crystals, 2020
Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS infection. A wet media milling top-down approach was used to develop and produce nano co-crystals of 3TC and AZT.
Bwalya A. Witika, Vincent J. Smith, Roderick B. Walker   +2 more
doaj   +1 more source

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

Pharmacology Research & Perspectives, 2022
UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of
Kaoru Kobayashi, Tsuneo Deguchi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Atsushi Kurihara, Mitsuo Oshimura, Yasuhiro Kazuki   +9 more
doaj   +1 more source