Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]
Fundam Clin PharmacolABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc +2 more sources
Preventing Mother to Child Transmission of Human Immunodeficiency Virus: 20-Year Trends in Management and Clinical Practice in a French Hospital - A Retrospective Observational Study. [PDF]
Health Sci RepABSTRACT Background and Aims Since the discovery of human immunodeficiency virus (HIV) mother to child transmission (MTCT), its prevention has been a priority. Guideline adherence has drastically reduced MTCT, virtually inexistent today in high‐income countries.
Dmitrenko B +5 more
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Infectious Diseases in Obstetrics and Gynecology, 1998 Zidovudine was the first agent approved for treatment of HIV disease, and since its widespread availability in 1987, the pharmacokinetic disposition and clinical effects of ZDV have been extensively evaluated. In addition to its utility as a component of a multidrug combination regimen for the treatment of adult and pediatric HIV-1 infection, it is the
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Post Exposure Prophylaxis for Occupational Exposures to HIV and Hepatitis B: Our Experience of Thirteen Years at a Rural Based Tertiary Care Teaching Hospital of Western India [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Health Care Workers (HCWs) are at risk of occupational transmission of HIV, Hepatitis B and Hepatitis C, which can be minimized by following guidelines for standard precautions as well as taking Post Exposure Prophylaxis (PEP) measures.
Sanket Pranjivan Sheth +2 more
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Hematological Changes in Women and Infants Exposed to an AZT-Containing Regimen for Prevention of Mother-to-child-transmission of HIV in Tanzania. [PDF]
, 2013 Tanzanian guidelines for prevention of mother-to-child-transmission of HIV (PMTCT) recommend an antiretroviral combination regimen involving zidovudine (AZT) during pregnancy, single-dosed nevirapine at labor onset, AZT plus Lamivudine (3TC) during ...
A Alioum +31 more
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Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in sub-Saharan Africa? [PDF]
, 2017 This version is the Accepted Manuscript and is published in final edited form as: AIDS. 2017 January 02; 31(1): 147–157. doi:10.1097/QAD.0000000000001307OBJECTIVE: We assessed the relationship between phasing out stavudine in first-line antiretroviral ...
Bor, Jacob +15 more
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Journal of Pharmaceutical Analysis, 2012 Simultaneous quantification of Lamivudine and Zidovudine in tablets by HPTLC method was developed and validated. The chromatograms were developed using a mobile phase of toluene:ethyl acetate:methanol (4:4:2, v/v/v) on pre-coated plate of silica gel GF ...
Palani Venkatesh, Mahesh Daggumati
doaj +1 more source
Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years. [PDF]
, 2011 The latest World Health Organization guidelines recommend replacing stavudine with tenofovir or zidovudine in first-line antiretroviral therapy in resource-limited settings.
Birkus +12 more
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Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom [PDF]
, 2001 Objectives: To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom. Design: Retrospective and prospective assessment of viruses obtained from people recently infected with HIV.
Baily, Guy +7 more
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