Results 11 to 20 of about 25,606 (215)

The study on the transport and phosphorylation kinetics of zidovudine in the Chinese population and its significance for individualized antiretroviral therapy [PDF]

Scientific Reports
Zidovudine (AZT), a nucleoside reverse transcriptase inhibitor, exerts its antiviral effect through intracellular conversion to AZT-triphosphate (AZT-TP), with therapeutic efficacy and toxicity closely linked to intracellular AZT-TP levels rather than ...
Fang Tang, Shan Ji, Xiujun Lai, Tao Yan, Jie Peng   +4 more
doaj   +2 more sources

Rejoinder to Commentaries on “A Perspective on the Appropriate Implementation of ICH E9(R1) Addendum Strategies for Handling Intercurrent Events” [PDF]

Stat Med
Statistics in Medicine, Volume 45, Issue 15-17, July 2026.
Thomas R. Fleming, Kevin J. Carroll, Janet T. Wittes, Scott S. Emerson, Mark D. Rothmann, Sylva Collins, Gregory Levin   +6 more
wiley   +2 more sources

Optimizing Identification and Care of Pregnant/Breastfeeding Women Living With HIV in Resource‐Limited Settings [PDF]

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Since the mid‐1990s, there have been major advances in diagnosing and providing antiretroviral therapy (ART) for pregnant women living with HIV (WLWH) in both resource‐rich and resource‐limited settings. Initial progress was based on the 1994 landmark perinatal trial, which showed 67% reduction in vertical transmission among ...
Mary Glenn Fowler, Victoria B. Chou, Philippa Musoke   +2 more
wiley   +2 more sources

Hemoglobin Levels in Patients with Human Immunodeficiency Virus Na ve Therapy Containing Zidovudine in the First Three Months [PDF]

, 2020
Background: Zidovudine, one of the combination antiretroviral used to treat HIV/AIDS, is the most common cause of anemia in HIV patients. Anemia related to zidovudine in HIV can worsen HIV infection.
Muhammad Vitanata Arfijanto, -, PRASETYANING ESTU PRATIWI, NIM011418026311, Usman Hadi, -   +2 more
core   +1 more source

Cost-effectiveness of tenofovir instead of zidovudine for use in first-line antiretroviral therapy in settings without virological monitoring. [PDF]

, 2012
BACKGROUND: The most recent World Health Organization (WHO) antiretroviral treatment guidelines recommend the inclusion of zidovudine (ZDV) or tenofovir (TDF) in first-line therapy.
Phillips, AN, Alec Miners, Valentina Cambiano (146513), von Wyl Viktor, Phillips, Andrew N, Andrew N Phillips, Bertagnolio, S, Cambiano, V, Jens Lundgren, Valentina Cambiano, Silvia Bertagnolio, Pillay Deenan, Pillay, Deenan, Deenan Pillay (7888), Bertagnolio, Silvia, Miners Alec, Jordan, MR, Michael R. Jordan (146520), Cambiano, Valentina, von Wyl, Viktor, Viktor von Wyl, Phillips Andrew N., Jordan, Michael R, Cambiano Valentina, Miners, Alec, Pillay, D, Bertagnolio Silvia, Lundgren Jens, Miners, A, Andrew N. Phillips (146556), Lundgren, Jens, Alec Miners (146534), Viktor von Wyl (146506), Silvia Bertagnolio (57174), Michael R Jordan, Deenan Pillay, von Wyl, V, Lundgren, J, Jens Lundgren (146550), Jordan Michael R.   +39 more
core   +1 more source

Zidovudine-β-Lactam Pronucleoside Strategy for Selective Delivery into Gram-Negative Bacteria Triggered by β‑Lactamases

, 2023
Addressing antibacterial resistance is a major concern of the modern world. The development of new approaches to meet this deadly threat is a critical priority.
Georges Feller (164932), Lindita Lari (16541098), Elodie Carretero, Lindita Lari, Filomena Sannio, Elodie Carretero (16541101), Federica Verdirosa (14197962), Miyanou Rosales-Hurtado, Patricia Licznar-Fajardo, Federica Verdirosa, Miyanou Rosales-Hurtado (16541095), Laurent Gavara, Filomena Sannio (5847152), Georges Feller, Yen Vo-Hoang, Patricia Licznar-Fajardo (9321851), Laurent Gavara (2067403), Yen Vo-Hoang (14197965), Jean-Denis Docquier (2615785), Jean-Denis Docquier   +19 more
core   +1 more source

Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae. [PDF]

, 2021
OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method.
Hu, Y, Coates, A
core   +1 more source

Adverse effects of zidovudine on rats vision: antioxidant and enzymology perspectives [PDF]

, 2014
Background: The biochemical effects of chronic administration of Zidovudine on intracranial auditory relay centre of adult Wistar rats has been studied and reported.
Nwose, Ezekiel Uba, Igbigbi, Patrick Sunday, Adjene, Josiah Obaghwarhievwo   +2 more
core   +1 more source

Impact of HIV infection and zidovudine therapy on RBC parameters and urine methylmalonic acid levels [PDF]

, 2016
Background. Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA ...
Uche, E., John-Olabode, S., Adediran, A., Osunkalu, V., Wakama, T., Akanmu, S., Akinbami, A.   +6 more
core   +1 more source

Lamivudine/abacavir maintains virological superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children [PDF]

, 2007
: Objective: To describe the long-term efficacy over 5 years of regimens including combinations of abacavir, lamivudine and/or zidovudine in previously untreated children in the PENTA 5 trial. Design: PENTA 5 was a 48-week randomised controlled trial
COMPAGNUCCI A, LEVY J, FEITERNA SPERLING C, BUTLER K, WALKER AS, WINTERGERST U, GIBB DM, GIAQUINTO, CARLO, SAIDI Y, DE ROSSI, ANITA, HARPER L, CANDEIAS E, CASTELLI GATTINARA G, PILLAY D, DELLA NEGRA M, Paediatric European Network for the Treatment of AIDS, GREEN H   +16 more
core   +2 more sources