Results 171 to 180 of about 1,296,858 (303)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Balancing public health needs and economic sustainability: A dual-matrix model for community pharmacy inventory management. [PDF]

Explor Res Clin Soc Pharm
Jelić AG, Vučenović VT, Vučenović S, Marković-Peković V, Kurdi A, Godman B, Meyer JC, Škrbić R.   +7 more
europepmc   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Learning-aided Artificial Bee Colony with neural knowledge transfer for global optimization. [PDF]

Sci Rep
Saini G, Jadon SS, Chaube S.
europepmc   +1 more source

Metarhizium anisopliae Mitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

Clinical subtypes in breast cancer patients with brain metastases from an ambispective registry of advanced breast cancer, GEICAM/2014-03 (RegistEM). [PDF]

Ther Adv Med Oncol
López-Tarruella S, Guerrero-Zotano Á, Antolín S, Cruz J, Martínez P, Rodríguez CA, Falo C, Rodríguez-Lescure Á, Adrover E, Hernández M, Andrés R, Chacón JI, Alonso Romero JL, Miguel A, Gómez-Raposo C, Margelí M, González I, Guerra JA, Antón A, Tibau A, Miralles JJ, Escudero MJ, Bezares S, Rojo F, Álvarez I.   +24 more
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Real-world effectiveness of antiretroviral backbone regimens on viral suppression in pediatric and adolescent HIV care: a six-year cohort study from Uganda. [PDF]

EClinicalMedicine
Ankunda C, Kyomuhangi B, Emunyu J, Namasambi S, Sserunjogi C, Nakawesi J.   +5 more
europepmc   +1 more source

Vacuum–Laser Fabrication of Programmable Soft Actuators

Advanced Science, EarlyView.
A rapid and accessible fabrication strategy for inflatable soft actuators is presented, combining vacuum sealing with laser cutting of low‐cost thermoplastic pouches. The method enables precise sealing, fast fabrication, and programmable multi‐cell geometries.
Ashkan Rezanejad, Mostafa Mousa, Yuxuan Wang, Michael Adlerstein, Junke Yao, Antonio E. Forte   +5 more
wiley   +1 more source

A continuous artificial bee colony algorithm for solving uncapacitated facility location problems. [PDF]

Sci Rep
An M, Xiang W, Jiang Y, Gao M, Meng X.
europepmc   +1 more source