Results 101 to 110 of about 81,965 (299)

Characterisation of the vibrio cholerae antibiotic resistance var operon [PDF]

, 2007
The discovery and use of antibiotics in the chemotherapy of bacterial infections has revolutionised medicine as it is today. Unfortunately, the progressive use of antibiotics has promoted the evolution of bacterial defences against these mediators and ...
Massam-Wu, Teresa
core  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Association of ATP‐binding cassette transporter genomic alterations and expressions with patient survival in breast and prostate cancer

Physiological Reports
ATP‐Binding Cassette (ABC) transporters play a key role in drug resistance and cancer progression. We analyzed the correlation between ABC transporter gene alterations and patient survival in breast and prostate cancers using large‐scale genomic datasets.
Abdulaziz H. Alanazi, Nidhi Shenoy, Payaningal R. Somanath   +2 more
doaj   +1 more source

Solid-state NMR investigations of the ATP binding cassette multidrug transporter LmrA

, 2006
The development of resistance to multiple drugs is a major problem in treatment of number of infectious diseases and cancer. The phenomenon of multidrug resistance (MDR) is based on the synergetic interplay of a number of mechanisms such as target ...
Siarheyeva, Alena
core  

Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex

, 2012
The loading of antigenic peptides onto major histocompatibility complex class I (MHC I) molecules is an essential step in the adaptive immune response against virally or malignantly transformed cells.
Abele, Rupert, Sabine Hulpke, Tampé, Robert, Ueda, Kazumitsu, Ueda, K., Kazumitsu Ueda, Tomioka, Maiko, Rupert Abele, Tomioka, M., Robert Tampé, Maiko Tomioka, Kremmer, E., Abele, R., Hulpke, S., Hulpke, Sabine, Kremmer, Elisabeth, Tampé, R., Elisabeth Kremmer   +17 more
core   +1 more source

A Dual‐Functional Biohybrid Nanorobot to Synergistically Eradicate Biofilm and Degrade Antibiotic Resistance Genes

Advanced Science, EarlyView.
A biohybrid nanorobot integrating lytic bacteriophage N4 with Pd nanozymes is developed for targeted eradication of multidrug‐resistant E. coli biofilms. Synergistic bacterial lysis and ROS‐mediated oxidation enable simultaneous biofilm removal and antibiotic resistance genes degradation, maintaining high efficacy in complex wastewater environments ...
Junzheng Zhang, Tong Dou, Luokai Wang, Jingxian Yang, Wenrui Wang, Shuaitian Guo, Xiangyu Li, Xuefang Huang, Yunlei Xianyu, Dongsheng Wang   +9 more
wiley   +1 more source

Mechanistic insights into ATP hydrolysis by the ABC transporter TAP

, 2004
The transporter associated with antigen processing (TAP) plays a pivotal role in the adaptive immune response against virus-infected or malignantly transformed cells.
Chen, Min
core  

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

A fungal ABC transporter FgAtm1 regulates iron homeostasis via the transcription factor cascade FgAreA-HapX.

PLoS Pathogens, 2019
Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown.
Zhihui Wang, Tianling Ma, Yunyan Huang, Jing Wang, Yun Chen, H Corby Kistler, Zhonghua Ma, Yanni Yin   +7 more
doaj   +1 more source

Transport and catabolism of murein tripeptide in Escherichia coli K-12 [PDF]

, 2011
In bacteria, extracellular peptides are not only a source of nutrients but also play important roles in cell-cell communication. The primary mode of uptake of these peptides in bacteria is via ATP Binding Cassette (ABC) transporters.
Maqbool, Abbas
core