Results 91 to 100 of about 81,965 (299)

The effect of cyanoquinoline inhibitors on growth of ABC transporter-proficient or ABC transporter-deficient cell lines.

, 2016
The effect of cyanoquinoline inhibitors on growth of ABC transporter-proficient or ABC transporter-deficient cell lines.
Federica Pisaneschi (2694046), Graham Smith (279803), Rozanna L. Slade (3072048), Alice Beckley (3072039), Quang-De Nguyen (2401156), Eric O. Aboagye (309960), Laurence Carroll (3072045), Maciej A. Kaliszczak (3072042)   +7 more
core   +1 more source

Frequent down-regulation of ABC transporter genes in prostate cancer [PDF]

, 2015
Background: ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes.
Feliksas Jankevicius, Juozas Rimantas Lazutka, Daniūnaitė, Kristina,, Jankevičius, Feliksas,, Deividas Razanauskas, Jarmalaitė, Sonata,, Sonata Jarmalaite, Demidenko, Rita,, Kristina Daniunaite, Rita Demidenko, Razanauskas, Deividas,, Lazutka, Juozas Rimantas,   +11 more
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

ABC transporter deficiency promotes anxiety.

, 2013
The diagrams show parameters assessed via the elevated plus maze. Mice deficient for ABCB1 (−44%) and ABCG2 (−32%) showed a significantly decreased presence in the open arms (A).
Anne-Sophie Plath (325434), Toni Schumacher (325416), Jacqueline Hofrichter (325421), Jan Stenzel (325426), Markus Krohn (325419), Johannes Steffen (325428), Christina Fröhlich (325431), Hans-Jochen Heinze (72737), Cathleen Lange (325424), Annekathrin Uecker (325432), Tina Dunkelmann (325429), Jens Pahnke (2589), Thomas Brüning (135293), Kristin Paarmann (325430), Alexandra Sommer (325436)   +14 more
core   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

The human ATP-binding cassette (ABC) transporter superfamily

Journal of Lipid Research, 2001
The transport of specific molecules across lipid membranes is an essential function of all living organisms and a large number of specific transporters have evolved to carry out this function.
Michael Dean, Yannick Hamon, Giovanna Chimini   +2 more
doaj   +1 more source

Transcriptomic insights on the ABC transporter gene family in the salmon louse Caligus rogercresseyi [PDF]

, 2015
Background  ATP-binding cassette (ABC) protein family encode for membrane proteins involved in the transport of various biomolecules through the cellular membrane.
Sturm, Armin, Armin Sturm, Valentina Valenzuela-Muñoz, Cristian Gallardo-Escárate, Valenzuela-Munoz, Valentina, Gallardo-Escarate, Cristian   +5 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB

, 2005
Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core