Molecular characterization of the ATPase component of a putative ABC type transporter in moraxella catarrhalis [PDF]
, 2004 Cataloged from PDF version of article.Moraxella catarrhalis is one of the major causes of respiratory tract and middle ear infections. Little is known about the pathogenesis of M. catarrhalis infection.
Şahin, Jale
core
Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. [PDF]
, 2014 In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ATP-binding cassette-type cysteine/GSH transporter, CydDC.
Baldwin, SA +9 more
core +3 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Function and Role of ATP-Binding Cassette Transporters as Receptors for 3D-Cry Toxins
Toxins, 2019 When ABC transporter family C2 (ABCC2) and ABC transporter family B1 (ABCB1) were heterologously expressed in non-susceptible cultured cells, the cells swelled in response to Cry1A and Cry3 toxins, respectively.
Ryoichi Sato +4 more
doaj +1 more source
Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications [PDF]
, 2015 ABC transporters are primary active transporters found in all kingdoms of life. Human multidrug resistance transporter ABCB1, or P-glycoprotein, has an extremely broad substrate spectrum and confers resistance against chemotherapy drug treatment in ...
Abe +83 more
core +1 more source
Gout, genetics and ABC transporters [PDF]
F1000 Biology Reports, 2011 Gout is a chronic arthritic disease associated with high levels of urate in blood. Recent advances in research have permitted the identification of several new and common genetic factors underlying the disease. Among them, a polymorphism in the ABC transporter gene ATP-binding cassette transporter isoform G2 has been highlighted.
Basseville, Agnès, Bates, Susan E.
openaire +2 more sources
Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy
Advanced Functional Materials, EarlyView.This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez +8 more
wiley +1 more source
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. [PDF]
PLoS ONE, 2011 Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding cassette (ABC) transporters, ATP-dependent efflux pumps.
Ayako Nakano +19 more
doaj +1 more source
Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]
, 2019 We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey +2 more
core +1 more source
ABC transporters: the power to change [PDF]
Nature Reviews Molecular Cell Biology, 2009 ATP-binding cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins that are responsible for the ATP-powered translocation of many substrates across membranes. The highly conserved ABC domains of ABC transporters provide the nucleotide-dependent engine that drives transport.
Rees, Douglas C. +2 more
openaire +3 more sources