Results 251 to 260 of about 138,806 (299)

The ABCs of Sterol Transport

Annual Review of Physiology, 2021
Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to ...
Ashlee M, Plummer   +2 more
openaire   +2 more sources

ABC transporters in lipid transport

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000
Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.
P, Borst, N, Zelcer, A, van Helvoort
openaire   +3 more sources

The ABC maltose transporter

Molecular Microbiology, 1998
Bacterial ATP‐binding cassette (ABC) transporters and their homologues in eukaryotic cells form one of the largest superfamilies known today. They function as primary pumps that couple substrate translocation across the cytoplasmic membrane to ATP hydrolysis.
Ehrmann, Michael   +4 more
openaire   +3 more sources

ABC transporters of staphylococci

Research in Microbiology, 2001
Some members of the genus Staphylococcus are important human pathogens, such as Staphylococcus aureus and Staphylococcus epidermidis. ATP binding cassette (ABC) transporters of pathogenic staphylococci are often responsible for antibiotic resistance and for the uptake of essential solutes and are therefore being considered as targets for novel ...
M, Otto, F, Götz
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Mitochondrial ABC transporters

Research in Microbiology, 2001
In contrast to bacteria, mitochondria contain only a few ATP binding cassette (ABC) transporters in their inner membrane. The known mitochondrial ABC proteins fall into two major classes that, in the yeast Saccharomyces cerevisiae, are represented by the half-transporter Atm1p and the two closely homologous proteins Mdl1p and Mdl2p. In humans two Atm1p
R, Lill, G, Kispal
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Leukemia and ABC Transporters

2015
Acute myeloid leukemia (AML) is a heterogeneous disease caused by aberrant proliferation and/or differentiation of myeloid progenitors. However, only ~65% of AML patients respond to induction chemotherapy and the overall survival rate for AML remains low (~24% for 5-year survival).
Yu, Fukuda   +2 more
openaire   +2 more sources

ABC Transporters and Neuroblastoma

2015
Neuroblastoma is the most common cancer of infancy and accounts for 15% of all pediatric oncology deaths. Survival rates of high-risk neuroblastoma remain less than 50%, with amplification of the MYCN oncogene the most important aberration associated with poor outcome. Direct transcriptional targets of MYCN include a number of ATP-binding cassette (ABC)
Denise M T, Yu   +4 more
openaire   +2 more sources

Structure of ABC transporters

Essays in Biochemistry, 2011
ABC (ATP-binding cassette) transporters are primary active membrane proteins that translocate solutes (allocrites) across lipid bilayers. The prototypical ABC transporter consists of four domains: two cytoplasmic NBDs (nucleotide-binding domains) and two TMDs (transmembrane domains).
Joseph K, Zolnerciks   +3 more
openaire   +2 more sources

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