Results 241 to 250 of about 138,806 (299)

The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake. [PDF]

Nat Commun
Gonda I, Sorrentino S, Galazzo L, Lichti NP, Arnold FM, Mehdipour AR, Bordignon E, Seeger MA.   +7 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

RNA thermometers are widespread upstream of ABC transporter genes in bacteria. [PDF]

J Biol Chem
Tong AY, Tong EL, Hannani MA, Shaffer SN, Santiago D, Ferré-D'Amaré AR, Passalacqua LFM, Abdelsayed MM.   +7 more
europepmc   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Genome wide structural prediction of ABC transporter systems in <i>Bacillus subtilis</i>. [PDF]

Front Microbiol
Mahendran A, Orlando BJ.
europepmc   +1 more source

Patterns of help‐seeking for mental health problems in 1001 self‐identified neurodivergent adolescents who self‐harm

JCPP Advances, EarlyView.
Adolescents who self‐harm are also more likely to seek support from informal than formal sources and least likely to seek support online. But neurodivergent adolescents who self‐harm are more likely to seek any and especially formal (pastoral school staff or mental health services) support than their peers.
Simona Skripkauskaite, Galit Geulayov, the OxWell Study Team, Mina Fazel, Rohan Borschmann   +4 more
wiley   +1 more source

Blood-CSF barrier clearance of ABC transporter substrates is suppressed by interleukin-6 in lupus choroid plexus spheroids. [PDF]

Fluids Barriers CNS
Reynolds JA, Torz L, Cummins L, Stock AD, Ben-Zvi A, Putterman C.   +5 more
europepmc   +1 more source

Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance. [PDF]

Proc Natl Acad Sci U S A
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L.   +20 more
europepmc   +1 more source

Inhibition and transport mechanisms of the ABC transporter hMRP5. [PDF]

Nat Commun
Huang Y, Xue C, Bu R, Wu C, Li J, Zhang J, Chen J, Shi Z, Chen Y, Wang Y, Liu Z.   +10 more
europepmc   +1 more source

Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC. [PDF]

Sci Adv
Qiao Z, Do PH, Yeo JY, Ero R, Li Z, Zhan L, Basak S, Gao YG.   +7 more
europepmc   +1 more source